2021
Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles
Wu XS, Subramanian S, Zhang Y, Shi B, Xia J, Li T, Guo X, El-Hassar L, Szigeti-Buck K, Henao-Mejia J, Flavell RA, Horvath TL, Jonas EA, Kaczmarek LK, Wu LG. Presynaptic Kv3 channels are required for fast and slow endocytosis of synaptic vesicles. Neuron 2021, 109: 938-946.e5. PMID: 33508244, PMCID: PMC7979485, DOI: 10.1016/j.neuron.2021.01.006.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCHO CellsCricetulusEndocytosisMiceMutationPresynaptic TerminalsShaw Potassium ChannelsSynaptic TransmissionSynaptic VesiclesConceptsSlow endocytosisVesicle mobilizationF-actin cytoskeletonChannel mutationsPotassium channelsKv3.3 proteinsInhibits endocytosisRapid endocytosisNovel functionF-actinEndocytosisCrucial functionSynaptic vesiclesFamily channelsSynaptic transmissionDiscovery decadesMembrane potentialNeurotransmitter releaseDiverse neurological disordersIon conductanceMutationsReleasable poolMouse nerve terminalsPotassium channel mutationsPathological effects
2003
How to Make a Relationship Last Release Sites with Different Levels of Commitment
Kaczmarek LK. How to Make a Relationship Last Release Sites with Different Levels of Commitment. Neuron 2003, 40: 7-9. PMID: 14527428, DOI: 10.1016/s0896-6273(03)00599-3.Peer-Reviewed Original Research
1998
High-frequency firing helps replenish the readily releasable pool of synaptic vesicles
Wang L, Kaczmarek L. High-frequency firing helps replenish the readily releasable pool of synaptic vesicles. Nature 1998, 394: 384-388. PMID: 9690475, DOI: 10.1038/28645.Peer-Reviewed Original ResearchConceptsReleasable poolPotassium channel blocker tetraethylammoniumChannel blocker Cd2Synaptic vesiclesPresynaptic action potentialHigh-frequency stimulationVoltage-gated Ca2Short-term synaptic depressionCentral nervous systemPatch-clamp recordingsHigh-frequency firingGiant synapsesPostsynaptic mechanismsBuffer EGTAMouse auditoryBlocker tetraethylammoniumSynaptic activitySynaptic depressionPresynaptic terminalsNervous systemAction potentialsRate of replenishmentSynapsesCa2Key signal