2002
HSV-1 Helper Virus 5dl1.2 Suppresses Sodium Currents in Amplicon-Transduced Neurons
White BH, Cummins TR, Wolf DH, Waxman SG, Russell DS, Kaczmarek LK. HSV-1 Helper Virus 5dl1.2 Suppresses Sodium Currents in Amplicon-Transduced Neurons. Journal Of Neurophysiology 2002, 87: 2149-2157. PMID: 11929932, DOI: 10.1152/jn.00498.2001.Peer-Reviewed Original ResearchConceptsSodium currentAnti-HSV antibodiesAverage spike frequencyWild-type HSV-1Helper virusViral-based strategiesDays of transductionCultured neuronsHSV-1Spike frequencyGene deliveryNeuronsMammalian neuronsAmplicon systemSimilar suppressionHSV-1 genesVirusTherapeutic purposesViral proteinsAmplicon preparationsCellsCoinfectionSuppressionPreparation resultsTiters
1998
Heterologous Expression of the Kv3.1 Potassium Channel Eliminates Spike Broadening and the Induction of a Depolarizing Afterpotential in the Peptidergic Bag Cell Neurons
Whim M, Kaczmarek L. Heterologous Expression of the Kv3.1 Potassium Channel Eliminates Spike Broadening and the Induction of a Depolarizing Afterpotential in the Peptidergic Bag Cell Neurons. Journal Of Neuroscience 1998, 18: 9171-9180. PMID: 9801357, PMCID: PMC6792887, DOI: 10.1523/jneurosci.18-22-09171.1998.Peer-Reviewed Original ResearchConceptsBag cell neuronsCell neuronsAction potentialsCalcium entryUse-dependent inactivationExpression of Kv3.1Kv3.1 potassium channelPeptidergic bag cell neuronsControl neuronsSpontaneous firingBrief synaptic stimulationCalcium currentNeuronal excitabilityIntracellular calciumCalcium influxSynaptic stimulationDepolarizing afterpotentialsBAPTA-AMAfterpotentialsNeuronsPotassium channelsClusters of cellsKv3.1InductionPhysiological role
1996
Cloning and Characterization of the Promoter for a Potassium Channel Expressed in High Frequency Firing Neurons (∗)
Gan L, Perney T, Kaczmarek L. Cloning and Characterization of the Promoter for a Potassium Channel Expressed in High Frequency Firing Neurons (∗). Journal Of Biological Chemistry 1996, 271: 5859-5865. PMID: 8621457, DOI: 10.1074/jbc.271.10.5859.Peer-Reviewed Original Research3T3 Cells8-Bromo Cyclic Adenosine MonophosphateAnimalsBase SequenceBinding SitesBucladesineCell DifferentiationChloramphenicol O-AcetyltransferaseCloning, MolecularCyclic AMPDNA PrimersDNA, ComplementaryFibroblastsGene ExpressionGenomic LibraryIonomycinKineticsMiceMolecular Sequence DataNeuronsNeuropeptidesPC12 CellsPlasmidsPodophyllinPodophyllotoxinPotassium ChannelsPotassium Channels, Voltage-GatedPromoter Regions, GeneticRatsRecombinant ProteinsRegulatory Sequences, Nucleic AcidRestriction MappingSequence DeletionShaw Potassium ChannelsTransfection