2013
The contribution of TWIK-1 channels to astrocyte K+ current is limited by retention in intracellular compartments
Wang W, Putra A, Schools GP, Ma B, Chen H, Kaczmarek LK, Barhanin J, Lesage F, Zhou M. The contribution of TWIK-1 channels to astrocyte K+ current is limited by retention in intracellular compartments. Frontiers In Cellular Neuroscience 2013, 7: 246. PMID: 24368895, PMCID: PMC3856854, DOI: 10.3389/fncel.2013.00246.Peer-Reviewed Original ResearchTWIK-1 channelsTWIK-1Plasma membraneIntracellular compartmentsMature hippocampal astrocytesTwo-pore domainWild-type animalsFractionation experimentsTwo-poreKnockout miceCytoplasmic fractionExpression of Kir4.1Compartment fractionsType animalsPhysiological conditionsTREK-1Whole-cell currentsLow-level presenceKnockoutLinear current-voltage relationshipCompartmentsMembraneMild effect
2003
The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight
Xu J, Koni PA, Wang P, Li G, Kaczmarek L, Wu Y, Li Y, Flavell RA, Desir GV. The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight. Human Molecular Genetics 2003, 12: 551-559. PMID: 12588802, DOI: 10.1093/hmg/ddg049.Peer-Reviewed Original ResearchConceptsBody weightBasal metabolic rateKv1.3 channelsDiet-induced obesityHigh-fat dietBody weight regulationT cell activationVoltage-gated potassium channel Kv1.3Voltage-gated potassium channelsPotassium channel Kv1.3Control littermatesFood intakeLittermate controlsKnockout miceWeight regulationIndirect calorimetryMetabolic rateChannel inhibitionCell activationEnergy homeostasisKnockout animalsPotassium channelsCell membrane potentialMiceChannel Kv1.3