2012
Regulation of Neuronal Excitability by Interaction of Fragile X Mental Retardation Protein with Slack Potassium Channels
Zhang Y, Brown MR, Hyland C, Chen Y, Kronengold J, Fleming MR, Kohn AB, Moroz LL, Kaczmarek LK. Regulation of Neuronal Excitability by Interaction of Fragile X Mental Retardation Protein with Slack Potassium Channels. Journal Of Neuroscience 2012, 32: 15318-15327. PMID: 23115170, PMCID: PMC3518385, DOI: 10.1523/jneurosci.2162-12.2012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnisomycinAplysiaCHO CellsCloning, MolecularCricetinaeCricetulusElectrophysiological PhenomenaFragile X Mental Retardation ProteinImmunohistochemistryImmunoprecipitationNeuronsPatch-Clamp TechniquesPotassium ChannelsProtein Synthesis InhibitorsRNA InterferenceRNA, Small InterferingSodiumSynapsesConceptsNeuronal excitabilitySlack potassium channelsTetrodotoxin-sensitive componentCurrent-clamp recordingsSlack channelsMental retardation proteinBag cell neuronsSustained componentIntracellular injectionNeuronal firingInhibitory periodSynaptic stimulationPotassium currentCell neuronsAction potentialsOutward currentsPotassium channelsProlonged changesNeuronsAplysia bag cell neuronsProtein synthesis inhibitor anisomycinExcitabilityFragile X Mental Retardation ProteinCommon formIntellectual disability
1980
Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture
Kaczmarek LK, Jennings KR, Strumwasser F, Nairn AC, Walter U, Wilson FD, Greengard P. Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture. Proceedings Of The National Academy Of Sciences Of The United States Of America 1980, 77: 7487-7491. PMID: 6261262, PMCID: PMC350530, DOI: 10.1073/pnas.77.12.7487.Peer-Reviewed Original ResearchConceptsCalcium action potentialsBag cell neuronsAction potentialsCell neuronsInput resistanceCalcium antagonistsControl injectionsIntracellular injectionAbdominal ganglionPotassium channelsProtein kinaseNeuronsPrimary culturesInjected cellsInjectionIntracellular microinjectionMembrane potentialSubthreshold oscillationsAMP-dependent protein kinaseMicroinjectionCell culturesCyclic AMP-dependent protein kinaseSpike enhancementCatalytic subunitExtracellular medium
1979
The morphology and coupling of Aplysia bag cells within the abdominal ganglion and in cell culture
Kaczmarek L, Finbow M, Revel J, Strumwasser F. The morphology and coupling of Aplysia bag cells within the abdominal ganglion and in cell culture. Developmental Neurobiology 1979, 10: 535-550. PMID: 521813, DOI: 10.1002/neu.480100604.Peer-Reviewed Original ResearchConceptsBag cell clustersBag cellsAbdominal ganglionLucifer YellowConnective tissueBag cell afterdischargeCell clustersSynchronous action potentialsIntracellular injectionIntact gangliaAction potentialsGangliaPrimary culturesNeurosecretory cellsDistal processesInjected cellsAfterdischargesCell actionGap junctionsSomaDye transferCellsPairs of cellsCell culturesCell processes