1993
Mode-switching of a voltage-gated cation channel is mediated by a protein kinase A-regulated tyrosine phosphatase
Wilson G, Kaczmarek L. Mode-switching of a voltage-gated cation channel is mediated by a protein kinase A-regulated tyrosine phosphatase. Nature 1993, 366: 433-438. PMID: 8247151, DOI: 10.1038/366433a0.Peer-Reviewed Original ResearchConceptsVoltage-gated cation channelsTyrosine phosphataseProtein kinase A. MoreoverProtein kinase ACation channelsAplysia bag cell neuronsBag cell neuronsKinase ATyrosine kinasePatch-clamp studiesPhosphataseGating modesCell neuronsA. MoreoverNeuronal excitabilityNervous system tissueKinaseCentral nervous system tissueEnzyme
1987
The role of protein kinase C in the regulation of ion channels and neurotransmitter release
Kaczmarek L. The role of protein kinase C in the regulation of ion channels and neurotransmitter release. Trends In Neurosciences 1987, 10: 30-34. DOI: 10.1016/0166-2236(87)90122-6.Peer-Reviewed Original ResearchProtein kinase CKinase CLipid environmentSecond messengerIntact cellsPhysiological activatorTypes of cellsAmount of neurotransmitterIon channelsChloride channelsPhorbol esterDiacylglycerolSynthetic diacylglycerolNeurotransmitter releaseEnzymeActivatorHormonal stimulationRegulationCellsImportant roleNervous systemNerve cellsMessengerActivityRole
1985
Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C
DeRiemer SA, Strong JA, Albert KA, Greengard P, Kaczmarek LK. Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C. Nature 1985, 313: 313-316. PMID: 2578617, DOI: 10.1038/313313a0.Peer-Reviewed Original ResearchConceptsProtein kinase CKinase CProtein kinase presentEndogenous protein kinase CKinase presentProtein kinase1Molecular mechanismsCellular componentsPhorbol ester TPAIon channelsPhorbol esterMammalian brainTumor-promoting phorbol ester TPAMollusc AplysiaPhysiological propertiesEnzymeNeuronal excitabilityDirect evidenceKinase1PhosphorylationProteinHigh concentrationsActivationAplysia