2013
Isoforms of the neuronal glutamate transporter gene, SLC1A1/EAAC1, negatively modulate glutamate uptake: relevance to obsessive-compulsive disorder
Porton B, Greenberg B, Askland K, Serra L, Gesmonde J, Rudnick G, Rasmussen S, Kao H. Isoforms of the neuronal glutamate transporter gene, SLC1A1/EAAC1, negatively modulate glutamate uptake: relevance to obsessive-compulsive disorder. Translational Psychiatry 2013, 3: e259-e259. PMID: 23695234, PMCID: PMC3669922, DOI: 10.1038/tp.2013.35.Peer-Reviewed Original ResearchConceptsExcellent candidate geneObsessive-compulsive disorderNeuronal glutamate transporterGenomic levelInternal promoterCandidate genesPartial colocalizationTransporter geneGene expressionGenetic studiesGlutamate uptakeEAAC1 transporterPrimary promoterEAAC1 proteinGlutamate transporter geneGenesPhysiological regulatorIsoformsTranscriptsExon 2Glutamate transportersGlutamatergic gene expressionPromoterPotential clinical utilityNeuronal glutamate transporter gene
2003
Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype
Ozaki N, Goldman D, Kaye W, Plotnicov K, Greenberg B, Lappalainen J, Rudnick G, Murphy D. Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Molecular Psychiatry 2003, 8: 933-936. PMID: 14593431, DOI: 10.1038/sj.mp.4001365.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnorexia NervosaAsperger SyndromeAutistic DisorderCarrier ProteinsFemaleGenotypeHumansMaleMembrane GlycoproteinsMembrane Transport ProteinsMolecular Sequence DataMutation, MissenseNerve Tissue ProteinsObsessive-Compulsive DisorderPedigreePhenotypePhobic DisordersPolymorphism, Single-Stranded ConformationalProtein Structure, TertiarySerotonin Plasma Membrane Transport Proteins