1993
Amphetamine derivatives interact with both plasma membrane and secretory vesicle biogenic amine transporters.
Schuldiner S, Steiner-Mordoch S, Yelin R, Wall S, Rudnick G. Amphetamine derivatives interact with both plasma membrane and secretory vesicle biogenic amine transporters. Molecular Pharmacology 1993, 44: 1227-31. PMID: 7903417.Peer-Reviewed Original ResearchMeSH Keywords3,4-MethylenedioxyamphetamineAnimalsBlood PlateletsCarrier ProteinsCattleCell MembraneChromaffin GranulesFenfluramineHumansIn Vitro TechniquesMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsN-Methyl-3,4-methylenedioxyamphetamineP-ChloroamphetamineReserpineSerotoninSerotonin Plasma Membrane Transport ProteinsConceptsVesicular amine transporterVesicular amine transportAmine transportersAmine transportSerotonin transportChromaffin granule membrane vesiclesPlasma membrane transportersBiogenic amine transportersPlasma membraneMembrane transportersMembrane vesiclesSubstrate siteVesicular transportersTransportersDelta pH
1992
p-Chloroamphetamine induces serotonin release through serotonin transporters.
Rudnick G, Wall S. p-Chloroamphetamine induces serotonin release through serotonin transporters. Biochemistry 1992, 31: 6710-8. PMID: 1322169, DOI: 10.1021/bi00144a010.Peer-Reviewed Original ResearchMeSH KeywordsBinding, CompetitiveBiological TransportBlood PlateletsCarrier ProteinsCell MembraneChloridesHumansHydrogen-Ion ConcentrationImipramineKineticsLithiumLithium ChlorideMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsP-ChloroamphetamineRadioisotope Dilution TechniqueSerotoninSerotonin Plasma Membrane Transport ProteinsTritiumConceptsPlasma membrane vesiclesMembrane vesiclesChromaffin granule membrane vesiclesVesicular amine transporterATP hydrolysisBovine adrenal chromaffin granulesSerotonin transporterAdrenal chromaffin granulesPrevents accumulationAmine transportersPresence of Mg2TransportersVesiclesChromaffin granulesModel systemDelta pHHuman plateletsATPEffluxManner characteristicAccumulationTransmembraneNaCl gradientPCA's abilityP-chloroamphetamineThe molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release.
Rudnick G, Wall S. The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 1817-1821. PMID: 1347426, PMCID: PMC48544, DOI: 10.1073/pnas.89.5.1817.Peer-Reviewed Original ResearchConceptsPlasma membrane vesiclesMembrane vesiclesAmine transportersVesicular amine transporterBiogenic amine transportersSecretory vesiclesPlasma membraneATP hydrolysisMolecular mechanismsBovine adrenal chromaffin granulesSerotonin transporterAdrenal chromaffin granulesTransportersDirect interactionVesiclesChromaffin granulesHuman plateletsManner characteristicEffluxTransmembraneATPMDMA actionMechanismBindingMembrane