2014
The number of intestinal bacteria is not critical for the enhancement of antitumor activity and reduction of intestinal toxicity of irinotecan by the Chinese herbal medicine PHY906 (KD018)
Lam W, Jiang Z, Guan F, Hu R, Liu SH, Chu E, Cheng YC. The number of intestinal bacteria is not critical for the enhancement of antitumor activity and reduction of intestinal toxicity of irinotecan by the Chinese herbal medicine PHY906 (KD018). BMC Complementary Medicine And Therapies 2014, 14: 490. PMID: 25510341, PMCID: PMC4302098, DOI: 10.1186/1472-6882-14-490.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Bacterial AgentsAntineoplastic Agents, PhytogenicBacteriaCamptothecinColonic NeoplasmsDrugs, Chinese HerbalFemaleGranulocyte Colony-Stimulating FactorHumansIntestinal MucosaIntestinesIrinotecanMiceNeutrophil InfiltrationPhytotherapyReceptors, G-Protein-CoupledRNA, MessengerTumor Necrosis Factor-alphaWeight LossConceptsBody weight lossAntibiotic treatmentCPT-11Tumor-bearing miceIntestinal bacteriaIntestinal toxicityStem cell markersAntitumor activityAnimal body weight lossCPT-11-treated miceCell markersMRNA expressionTNF-alpha mRNA expressionWeight lossAntibiotic treatment groupCPT-11 treatmentCytokines G-CSFProgenitor/stem cell markersLactobacillus/EnterococcusIntestinal damageInflammatory processIntestinal bacterial profilesTreatment groupsPCNA stainingTumor allografts
2010
The Four-Herb Chinese Medicine PHY906 Reduces Chemotherapy-Induced Gastrointestinal Toxicity
Lam W, Bussom S, Guan F, Jiang Z, Zhang W, Gullen EA, Liu SH, Cheng YC. The Four-Herb Chinese Medicine PHY906 Reduces Chemotherapy-Induced Gastrointestinal Toxicity. Science Translational Medicine 2010, 2: 45ra59. PMID: 20720216, DOI: 10.1126/scitranslmed.3001270.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic Agents, PhytogenicApoptosisBeta CateninBiomarkers, TumorBromodeoxyuridineCamptothecinCell ProliferationDNA DamageDrugs, Chinese HerbalGastrointestinal TractGlucuronidaseHumansInflammationIrinotecanMedicine, Chinese TraditionalMiceProliferating Cell Nuclear AntigenRecovery of FunctionSignal TransductionStem CellsTransplantation, HomologousWeight LossWnt ProteinsWnt3 ProteinWnt3A ProteinConceptsCPT-11Gastrointestinal toxicityFour-herb Chinese medicine formulaPhase I/II clinical studyTumor necrosis factor-alpha expressionChemotherapy-induced gastrointestinal toxicityNecrosis factor-alpha expressionInducible nitric oxide synthaseProinflammatory cytokine concentrationsInfiltration of neutrophilsAnti-inflammatory effectsII clinical studyAnimal weight lossCPT-11 treatmentNitric oxide synthaseChinese medicine formulaNuclear factor-kappaBHuman embryonic kidney 293 cellsEmbryonic kidney 293 cellsAllograft modelCytokine concentrationsIntestinal toxicityOxide synthaseCyclooxygenase-2Clinical studies