2011
Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment
Wang E, Bussom S, Chen J, Quinn C, Bedognetti D, Lam W, Guan F, Jiang Z, Mark Y, Zhao Y, Stroncek DF, White J, Marincola FM, Cheng YC. Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment. BMC Medical Genomics 2011, 4: 38. PMID: 21569348, PMCID: PMC3117677, DOI: 10.1186/1755-8794-4-38.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCamptothecinCell Line, TumorCell ProliferationColonic NeoplasmsDrug InteractionsDrugs, Chinese HerbalFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHep G2 CellsHumansImmunityImmunohistochemistryInflammationIrinotecanLiverMacrophagesMedicine, Chinese TraditionalMiceOrgan SizePolymerase Chain ReactionReproducibility of ResultsRNA, MessengerSignal TransductionSpleenTumor MicroenvironmentConceptsCPT-11Subcutaneous colon 38 tumoursChinese medicinePro-inflammatory pathwaysPre-clinical modelsColon 38 tumorsBDF-1 miceTraditional Chinese medicineRNA microarray technologyTumor rejectionInflammatory processPharmacodynamic propertiesAntitumor effectsSide effectsTCM formulaAnimal studiesPrevalent inductionTherapeutic effectivenessPHY906Tumor tissueTumor microenvironmentGood manufacturing practicesTumorsDistinct alterationsTissue-specific responses
2010
The Four-Herb Chinese Medicine PHY906 Reduces Chemotherapy-Induced Gastrointestinal Toxicity
Lam W, Bussom S, Guan F, Jiang Z, Zhang W, Gullen EA, Liu SH, Cheng YC. The Four-Herb Chinese Medicine PHY906 Reduces Chemotherapy-Induced Gastrointestinal Toxicity. Science Translational Medicine 2010, 2: 45ra59. PMID: 20720216, DOI: 10.1126/scitranslmed.3001270.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic Agents, PhytogenicApoptosisBeta CateninBiomarkers, TumorBromodeoxyuridineCamptothecinCell ProliferationDNA DamageDrugs, Chinese HerbalGastrointestinal TractGlucuronidaseHumansInflammationIrinotecanMedicine, Chinese TraditionalMiceProliferating Cell Nuclear AntigenRecovery of FunctionSignal TransductionStem CellsTransplantation, HomologousWeight LossWnt ProteinsWnt3 ProteinWnt3A ProteinConceptsCPT-11Gastrointestinal toxicityFour-herb Chinese medicine formulaPhase I/II clinical studyTumor necrosis factor-alpha expressionChemotherapy-induced gastrointestinal toxicityNecrosis factor-alpha expressionInducible nitric oxide synthaseProinflammatory cytokine concentrationsInfiltration of neutrophilsAnti-inflammatory effectsII clinical studyAnimal weight lossCPT-11 treatmentNitric oxide synthaseChinese medicine formulaNuclear factor-kappaBHuman embryonic kidney 293 cellsEmbryonic kidney 293 cellsAllograft modelCytokine concentrationsIntestinal toxicityOxide synthaseCyclooxygenase-2Clinical studies