The Four-Herb Chinese Medicine PHY906 Reduces Chemotherapy-Induced Gastrointestinal Toxicity
Lam W, Bussom S, Guan F, Jiang Z, Zhang W, Gullen EA, Liu SH, Cheng YC. The Four-Herb Chinese Medicine PHY906 Reduces Chemotherapy-Induced Gastrointestinal Toxicity. Science Translational Medicine 2010, 2: 45ra59. PMID: 20720216, DOI: 10.1126/scitranslmed.3001270.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic Agents, PhytogenicApoptosisBeta CateninBiomarkers, TumorBromodeoxyuridineCamptothecinCell ProliferationDNA DamageDrugs, Chinese HerbalGastrointestinal TractGlucuronidaseHumansInflammationIrinotecanMedicine, Chinese TraditionalMiceProliferating Cell Nuclear AntigenRecovery of FunctionSignal TransductionStem CellsTransplantation, HomologousWeight LossWnt ProteinsWnt3 ProteinWnt3A ProteinConceptsCPT-11Gastrointestinal toxicityFour-herb Chinese medicine formulaPhase I/II clinical studyTumor necrosis factor-alpha expressionChemotherapy-induced gastrointestinal toxicityNecrosis factor-alpha expressionInducible nitric oxide synthaseProinflammatory cytokine concentrationsInfiltration of neutrophilsAnti-inflammatory effectsII clinical studyAnimal weight lossCPT-11 treatmentNitric oxide synthaseChinese medicine formulaNuclear factor-kappaBHuman embryonic kidney 293 cellsEmbryonic kidney 293 cellsAllograft modelCytokine concentrationsIntestinal toxicityOxide synthaseCyclooxygenase-2Clinical studies