Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70
Wang Y, Lam W, Chen SR, Guan FL, Dutchman GE, Francis S, Baker DC, Cheng YC. Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70. Scientific Reports 2016, 6: 32832. PMID: 27596272, PMCID: PMC5011780, DOI: 10.1038/srep32832.Peer-Reviewed Original ResearchMeSH Keywords3' Untranslated RegionsAllosteric RegulationCarcinoma, HepatocellularCell ProliferationCyclin D1HSC70 Heat-Shock ProteinsHumansIndolizinesLiver NeoplasmsPhenanthrenesProtein BindingProtein Processing, Post-TranslationalTumor Cells, CulturedConceptsCyclin D1 translationShock cognate protein 70D1 translationRNA binding motifsHeat shock cognate protein 70Cellular regulatory proteinsNovel regulatory mechanismProtein 70UTR of mRNAsCyclin D1Chaperone activityAllosteric regulationProtein translationRegulatory proteinsElongation stepATP hydrolysisBinding motifRegulatory mechanismsAUUUA motifsMolecular mechanismsCyclin D1 mRNAProcessing complexElevated expressionHsc70MRNA