2021
YIV-906 potentiated anti-PD1 action against hepatocellular carcinoma by enhancing adaptive and innate immunity in the tumor microenvironment
Yang X, Lam W, Jiang Z, Guan F, Han X, Hu R, Cai W, Cheng W, Liu SH, Cheng P, Cai Y, Rattray NJW, Johnson CH, Chen L, Cheng YC. YIV-906 potentiated anti-PD1 action against hepatocellular carcinoma by enhancing adaptive and innate immunity in the tumor microenvironment. Scientific Reports 2021, 11: 13482. PMID: 34188068, PMCID: PMC8242098, DOI: 10.1038/s41598-021-91623-3.Peer-Reviewed Original ResearchConceptsM1-like macrophage polarizationMacrophage polarizationIDO activityInterferon gammaInnate immunityTumor microenvironmentTraditional Chinese herbal formulationPD-L1 inductionM1-like macrophagesAdaptive immune responsesM2 macrophage polarizationChinese herbal formulationTumor bearing miceQuality of lifeAnti-tumor activityGastrointestinal symptomsMonocytic MDSCsProlong survivalImmune toleranceAcute inflammationCancer patientsClinical resultsHepatocellular carcinomaImmune responseRadiation therapy
2011
Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment
Wang E, Bussom S, Chen J, Quinn C, Bedognetti D, Lam W, Guan F, Jiang Z, Mark Y, Zhao Y, Stroncek DF, White J, Marincola FM, Cheng YC. Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment. BMC Medical Genomics 2011, 4: 38. PMID: 21569348, PMCID: PMC3117677, DOI: 10.1186/1755-8794-4-38.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCamptothecinCell Line, TumorCell ProliferationColonic NeoplasmsDrug InteractionsDrugs, Chinese HerbalFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHep G2 CellsHumansImmunityImmunohistochemistryInflammationIrinotecanLiverMacrophagesMedicine, Chinese TraditionalMiceOrgan SizePolymerase Chain ReactionReproducibility of ResultsRNA, MessengerSignal TransductionSpleenTumor MicroenvironmentConceptsCPT-11Subcutaneous colon 38 tumoursChinese medicinePro-inflammatory pathwaysPre-clinical modelsColon 38 tumorsBDF-1 miceTraditional Chinese medicineRNA microarray technologyTumor rejectionInflammatory processPharmacodynamic propertiesAntitumor effectsSide effectsTCM formulaAnimal studiesPrevalent inductionTherapeutic effectivenessPHY906Tumor tissueTumor microenvironmentGood manufacturing practicesTumorsDistinct alterationsTissue-specific responses