2021
Prospective: Evolution of Chinese Medicine to Treat COVID-19 Patients in China
Wu J, Sun B, Hou L, Guan F, Wang L, Cheng P, Scobell S, Cheng YC, Lam W. Prospective: Evolution of Chinese Medicine to Treat COVID-19 Patients in China. Frontiers In Pharmacology 2021, 11: 615287. PMID: 33716728, PMCID: PMC7947616, DOI: 10.3389/fphar.2020.615287.Peer-Reviewed Original ResearchTraditional Chinese medicineMaxingshigan decoctionChinese medicineCOVID-19COVID-19 patientsUnique medical needsPublic health measuresNovel coronavirus diseaseBradykinin stormConventional antiviralsHuo-XueAngiotensin systemSystemic inflammationAntiviral effectAntiviral actionIndividual herbsMedical needHealth measuresCoronavirus diseaseUnderlying mechanismOral formulaPathogenesisDiseaseProspective articlesBotanical treatments
2016
Antibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion Substrates
Tsou LK, Lara-Tejero M, RoseFigura J, Zhang ZJ, Wang YC, Yount JS, Lefebre M, Dossa PD, Kato J, Guan F, Lam W, Cheng YC, Galán J, Hang HC. Antibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion Substrates. Journal Of The American Chemical Society 2016, 138: 2209-2218. PMID: 26847396, PMCID: PMC4831573, DOI: 10.1021/jacs.5b11575.Peer-Reviewed Original ResearchConceptsVirulence pathwaysType III protein secretionType III secretion system effectorsSpecific plant metabolitesSPI-1 T3SSSecretion system effectorsS. typhimurium invasionSalmonella enterica serovar TyphimuriumSecretion substratesEnterica serovar TyphimuriumTraditional Chinese medicineUnappreciated mechanismPlant metabolitesTyphimurium invasionProtein secretionSerovar TyphimuriumAntibacterial flavonoidsBacterial invasionEpithelial cellsSpecific flavonoidsBacterial growthMedicinal plantsPathwayPotential mechanismsInvasion
2011
Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment
Wang E, Bussom S, Chen J, Quinn C, Bedognetti D, Lam W, Guan F, Jiang Z, Mark Y, Zhao Y, Stroncek DF, White J, Marincola FM, Cheng YC. Interaction of a traditional Chinese Medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment. BMC Medical Genomics 2011, 4: 38. PMID: 21569348, PMCID: PMC3117677, DOI: 10.1186/1755-8794-4-38.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCamptothecinCell Line, TumorCell ProliferationColonic NeoplasmsDrug InteractionsDrugs, Chinese HerbalFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHep G2 CellsHumansImmunityImmunohistochemistryInflammationIrinotecanLiverMacrophagesMedicine, Chinese TraditionalMiceOrgan SizePolymerase Chain ReactionReproducibility of ResultsRNA, MessengerSignal TransductionSpleenTumor MicroenvironmentConceptsCPT-11Subcutaneous colon 38 tumoursChinese medicinePro-inflammatory pathwaysPre-clinical modelsColon 38 tumorsBDF-1 miceTraditional Chinese medicineRNA microarray technologyTumor rejectionInflammatory processPharmacodynamic propertiesAntitumor effectsSide effectsTCM formulaAnimal studiesPrevalent inductionTherapeutic effectivenessPHY906Tumor tissueTumor microenvironmentGood manufacturing practicesTumorsDistinct alterationsTissue-specific responses