A non‐GPCR dependent role for P‐Rex1 in endothelial cells
Naikawadi R, Cheng N, Wu D, Ye R. A non‐GPCR dependent role for P‐Rex1 in endothelial cells. The FASEB Journal 2011, 25: 631.9-631.9. DOI: 10.1096/fasebj.25.1_supplement.631.9.Peer-Reviewed Original ResearchHuman lung microvascular endothelial cellsTransendothelial electrical resistanceEndothelial cellsCultured human lung microvascular endothelial cellsLung vascular injuryVascular endothelial functionLung microvascular endothelial cellsVital organ functionLoss of TNFNeutrophil transendothelial migrationMicrovascular endothelial cellsVascular endothelial integrityTNF-α signalingP-Rex1Reactive oxygen species productionNeutrophil infiltrationEndothelial functionIntercellular gap formationVascular injurySmall interference RNAInflammatory tissueOxygen species productionVascular permeabilityTherapeutic targetOrgan function