2012
P‐Rex1 is critical for vascular hyper‐permeability and edema in the lungs
Naikawadi R, Cheng N, Vogel S, Wu D, Malik A, Ye R. P‐Rex1 is critical for vascular hyper‐permeability and edema in the lungs. The FASEB Journal 2012, 26: 842.10-842.10. DOI: 10.1096/fasebj.26.1_supplement.842.10.Peer-Reviewed Original ResearchHuman lung microvascular endothelial cellsCultured human lung microvascular endothelial cellsEndothelial cellsLung vascular injuryLung microvascular endothelial cellsPotential therapeutic targetNeutrophil transendothelial migrationEndothelial barrier disruptionMicrovascular endothelial cellsICAM-1 inductionP-Rex1G protein-coupled receptorsReactive oxygen species productionNeutrophil infiltrationProtein-coupled receptorsBarrier disruptionIntercellular gap formationVascular injurySmall interference RNAInflammatory tissueOxygen species productionVascular permeabilityPI3K dependent mannerKnockout miceTherapeutic target
2011
A non‐GPCR dependent role for P‐Rex1 in endothelial cells
Naikawadi R, Cheng N, Wu D, Ye R. A non‐GPCR dependent role for P‐Rex1 in endothelial cells. The FASEB Journal 2011, 25: 631.9-631.9. DOI: 10.1096/fasebj.25.1_supplement.631.9.Peer-Reviewed Original ResearchHuman lung microvascular endothelial cellsTransendothelial electrical resistanceEndothelial cellsCultured human lung microvascular endothelial cellsLung vascular injuryVascular endothelial functionLung microvascular endothelial cellsVital organ functionLoss of TNFNeutrophil transendothelial migrationMicrovascular endothelial cellsVascular endothelial integrityTNF-α signalingP-Rex1Reactive oxygen species productionNeutrophil infiltrationEndothelial functionIntercellular gap formationVascular injurySmall interference RNAInflammatory tissueOxygen species productionVascular permeabilityTherapeutic targetOrgan function
2010
P‐Rex1 regulates lung microvascular permeability
Naikawadi R, Cheng N, Wu D, Ye R. P‐Rex1 regulates lung microvascular permeability. The FASEB Journal 2010, 24: lb554-lb554. DOI: 10.1096/fasebj.24.1_supplement.lb554.Peer-Reviewed Original ResearchAcute lung injuryLung microvascular permeabilityPolymorphonuclear leukocytesLung injuryEndothelial cellsP-Rex1 expressionMicrovascular permeabilityLung microvascular endothelial cellsGram-negative bacterial infectionsTNF-alpha contributesWild-type miceMicrovascular endothelial cellsEndothelial barrier permeabilityP-Rex1Endothelial cell signalingBacterial clearanceTNF-alphaReactive oxygen species generationBarrier permeabilityType miceMajor cytokineKnockout miceBacterial infectionsSepticemic infectionUncontrolled activation