2024
Single-cell RNA-seq analysis of cell-cell communications in human lung reveals a novel role of VEGF-D in acute lung injury
Yuan Y, Sharma L, Tang W, Raredon M, Ahangari F, Khoury J, Wu D, Niklason L, Kaminski N. Single-cell RNA-seq analysis of cell-cell communications in human lung reveals a novel role of VEGF-D in acute lung injury. Physiology 2024, 39: 1314. DOI: 10.1152/physiol.2024.39.s1.1314.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisAcute lung injuryChronic obstructive pulmonary diseaseAcute respiratory distress syndromeAnalysis of cell-cell communicationVEGF-DMicrovascular nicheSingle-cell RNA-seqLung injury modelSingle-cell RNA-seq analysisLung injuryCell-cell communicationLigand-receptor pairsLPS-induced lung injury modelRNA-seqAdjacent cell typesPulmonary diseaseInjury modelHuman lung endothelial cellsBarrier functionImmune cell infiltrationTumor necrosis factor-aRespiratory distress syndromeLung vascular integrityGene expressionVEGF-D Is Enriched in the Human Lung Microvascular Niche and Improves Vascular Integrity During Acute Lung Injury
Yuan Y, Sharma L, Tang W, Raredon M, Ahangari F, Khoury J, Wu D, Niklason L, Kaminski N. VEGF-D Is Enriched in the Human Lung Microvascular Niche and Improves Vascular Integrity During Acute Lung Injury. 2024, a4694-a4694. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4694.Peer-Reviewed Original ResearchAcute lung injuryImproving vascular integrity
2010
P‐Rex1 regulates lung microvascular permeability
Naikawadi R, Cheng N, Wu D, Ye R. P‐Rex1 regulates lung microvascular permeability. The FASEB Journal 2010, 24: lb554-lb554. DOI: 10.1096/fasebj.24.1_supplement.lb554.Peer-Reviewed Original ResearchAcute lung injuryLung microvascular permeabilityPolymorphonuclear leukocytesLung injuryEndothelial cellsP-Rex1 expressionMicrovascular permeabilityLung microvascular endothelial cellsGram-negative bacterial infectionsTNF-alpha contributesWild-type miceMicrovascular endothelial cellsEndothelial barrier permeabilityP-Rex1Endothelial cell signalingBacterial clearanceTNF-alphaReactive oxygen species generationBarrier permeabilityType miceMajor cytokineKnockout miceBacterial infectionsSepticemic infectionUncontrolled activation