2014
Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis
Lee MY, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano AK, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood DA, Ferguson SM, De Camilli P, Sessa WC. Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis. Development 2014, 141: 1465-1472. PMID: 24598168, PMCID: PMC3957370, DOI: 10.1242/dev.104539.Peer-Reviewed Original ResearchConceptsΒ1 integrinFocal adhesion sizeGrowth factor signalingVascular endothelial growth factor signalingEndocytic turnoverIntegrin endocytosisDynamin 2Adhesion sizeFactor signalingDevelopmental angiogenesisAngiogenic sproutingCell migrationCultured endothelial cellsMultiple integrinsInducible lossIntegrinsMorphogenesisActivation stateDNM2Endothelial cellsAngiogenesisVivoEndocytosisSurface levelSignaling
2008
JAM-L–mediated leukocyte adhesion to endothelial cells is regulated in cis by α4β1 integrin activation
Luissint AC, Lutz PG, Calderwood DA, Couraud PO, Bourdoulous S. JAM-L–mediated leukocyte adhesion to endothelial cells is regulated in cis by α4β1 integrin activation. Journal Of Cell Biology 2008, 183: 1159-1173. PMID: 19064666, PMCID: PMC2600739, DOI: 10.1083/jcb.200805061.Peer-Reviewed Original ResearchConceptsJunctional adhesion moleculeIntegrin activationIntegrin-dependent adhesionIntegrin VLA-4Endothelial cellsAdhesion moleculesEpithelial adhesion moleculesJAM familyHeterophilic interactionsCis dimerizationDimerization stateVLA-4Monomeric formLeukocyte integrin VLA-4CellsActivationAdhesionComplexesProteinMoleculesDimerizationLeukocyte adhesionRecruitmentAccumulationFamily