2012
Zasp regulates integrin activation
Bouaouina M, Jani K, Long JY, Czerniecki S, Morse EM, Ellis SJ, Tanentzapf G, Schöck F, Calderwood DA. Zasp regulates integrin activation. Journal Of Cell Science 2012, 125: 5647-5657. PMID: 22992465, PMCID: PMC3575701, DOI: 10.1242/jcs.103291.Peer-Reviewed Original ResearchConceptsIntegrin activationDomain-containing proteinsExtracellular matrixHeterodimeric adhesion receptorsPDZ motif-containing proteinΑ5β1 integrinMammalian tissue cultureScaffold proteinCytoplasmic tailFirst proteinECM ligandsMuscle contractile machineryΒ-integrinExtracellular domainAdhesion receptorsIntegrin heterodimersTalinConformational changesHigh-affinity bindingEssential processProteinIntegrinsHuman cardiomyopathyZASPTissue culture
2006
Integrins in the Ovary
Monniaux D, Huet-Calderwood C, Bellego F, Fabre S, Monget P, Calderwood D. Integrins in the Ovary. Seminars In Reproductive Medicine 2006, 24: 251-261. PMID: 16944422, DOI: 10.1055/s-2006-948554.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRole of integrinsSperm ADAMsActin cytoskeletonExtracellular matrix componentsIntegrin tailsMultiple signalingOocyte integrinsOvarian surface epithelium cellsIntegrin functionConformational changesExtracellular matrixIntegrinsCell proliferationMatrix componentsTumor developmentMajor receptorIntegrin expressionSurface epithelium cellsPossible involvementPotential roleFollicular cellsGranulosa cellsCellsFollicular basement membraneEpithelium cells
2004
Integrin activation
Calderwood DA. Integrin activation. Journal Of Cell Science 2004, 117: 657-666. PMID: 14754902, DOI: 10.1242/jcs.01014.Peer-Reviewed Original ResearchConceptsIntegrin cytoplasmic domainExtracellular matrixCell-ECM adhesionIntegrin extracellular domainCytoskeletal protein talinTransmembrane adhesion receptorsAbility of cellsMulticellular organismsProtein talinExtracellular ligandsCytoplasmic domainIntegrin activationIntracellular signalsExtracellular domainAdhesion receptorsIntegrin familyConformational changesIntegrin receptorsIntracellular stepsReversible mechanismRecent studiesAdhesionTalinReceptorsOrganisms