Blocking Fas signaling in adipose tissue ameliorates obesity-associated inflammation, insulin resistance, and hepatosteatosis
Beloor J, Ullah I, Kim J, Choi C, Kim S, Chung K, KR J, Yi Y, Rhim T, Kumar P, Lee S. Blocking Fas signaling in adipose tissue ameliorates obesity-associated inflammation, insulin resistance, and hepatosteatosis. Journal Of Pharmaceutical Investigation 2024, 54: 519-537. DOI: 10.1007/s40005-024-00668-9.Peer-Reviewed Original ResearchFas signalingMatrix-assisted laser desorption/ionization-time of flight spectrometryBlock Fas signalingNon-apoptotic signalsMatrix-assisted laser desorption/ionization-timeNon-apoptotic pathwaysAdipose tissue macrophagesHigh-fat diet-induced obese mouse modelImpaired insulin signalingInsulin resistanceDiet-induced obesity mouse modelDUTP nick end labeling assayRecruitment of adipose tissue macrophagesFas receptorInsulin signalingPeptide polymerizationNick end labeling assayTissue macrophagesAdipocyte apoptosisSuppress production of inflammatory cytokinesTerminal deoxynucleotidyl transferase dUTP nick end labeling assayReal-time PCRDeoxynucleotidyl transferase dUTP nick end labeling assayObese mouse modelGene expressionTargeted siRNA delivery to lung epithelia reduces airway inflammation in a mouse model of allergic asthma
Ullah I, Choi H, Choi C, Chung K, Jung J, Yun G, Heo S, Yi Y, Kang E, Kim S, Yoon H, Rhim T, Lee S. Targeted siRNA delivery to lung epithelia reduces airway inflammation in a mouse model of allergic asthma. Biotechnology And Bioprocess Engineering 2024, 29: 97-108. DOI: 10.1007/s12257-024-00027-3.Peer-Reviewed Original ResearchLung epithelial cellsEpithelial cellsAirway inflammationIL-4RAIL-13IL-4Mouse modelMouse model of allergic asthmaModel of allergic asthmaAllergic pulmonary inflammationCultured lung epithelial cellsReduce airway inflammationInterleukin (IL)-4Asthma mouse modelIL-4 receptorMulti-subunit receptorModel in vivoHypersecretion of mucusIL-4 signalingOvalbumin sensitizationTh2 cytokinesPulmonary inflammationAirway hyperresponsivenessAllergic asthmaLung epithelia