2022
Toward a hypothesis‐free understanding of how phosphorylation dynamically impacts protein turnover
Li W, Salovska B, Fornasiero E, Liu Y. Toward a hypothesis‐free understanding of how phosphorylation dynamically impacts protein turnover. Proteomics 2022, 23: e2100387. PMID: 36422574, PMCID: PMC10964180, DOI: 10.1002/pmic.202100387.Peer-Reviewed Original ResearchConceptsPost-translational modificationsProtein turnoverDynamic stable isotope labelingCell starvationStable isotope labelingData-independent acquisition mass spectrometryAcquisition mass spectrometryProteome levelTurnover diversityPhosphoproteomic datasetsPhosphorylation stoichiometryMetabolic labelingIsotope labelingMass spectrometryPhosphorylationAmino acidsCell culturesBiological perspectiveStarvationTurnoverTurnover measurementsRecent studiesSILACProteoformsPeptidoforms
2015
Chemical inhibition of DNA repair kinases as a promising tool in oncology
Durisova K, Salovska B, Pejchal J, Tichy A. Chemical inhibition of DNA repair kinases as a promising tool in oncology. Biomedical Papers 2015, 160: 11-19. PMID: 26498210, DOI: 10.5507/bp.2015.046.Peer-Reviewed Original ResearchConceptsDNA-dependent protein kinaseDNA repair pathwaysRepair pathwaysDNA repairSpecific DNA repair pathwaysKey DNA repairDNA-damaging agentsSmall molecule inhibitorsATM-Rad3Protein kinaseAtaxia telangiectasiaChemical inhibitionKinaseMolecule inhibitorsSpecific inhibitorPathwayPotent inhibitorInhibitorsRecent studiesTumor resistanceTumor cellsMajor roleRadiotherapy efficiencyRepairCells
2013
DNA-dependent protein kinase and its inhibition in support of radiotherapy
Novotná E, Tichý A, Pejchal J, Lukášová E, Šalovská B, Vávrová J. DNA-dependent protein kinase and its inhibition in support of radiotherapy. International Journal Of Radiation Biology 2013, 89: 416-423. PMID: 23362996, DOI: 10.3109/09553002.2013.767993.Peer-Reviewed Original ResearchConceptsDNA-dependent protein kinaseRadiation-induced double strand break repairProtein kinaseDouble-strand break repairDNA repair proteinsDNA-PK inhibitionDNA-PK inhibitorKey DNA repair enzymeDNA repair enzymeBreak repairRepair proteinsPersonalized anti-cancer therapyRepair enzymesMolecular approachesMolecular mechanismsAnti-cancer therapyRecent discoveryCancer cellsKinaseRecent knowledgeRNASmall peptidesPivotal roleRecent studiesCancer therapy