1992
Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase.
Countaway J, Nairn A, Davis R. Mechanism of desensitization of the epidermal growth factor receptor protein-tyrosine kinase. Journal Of Biological Chemistry 1992, 267: 1129-1140. PMID: 1309762, DOI: 10.1016/s0021-9258(18)48406-2.Peer-Reviewed Original ResearchConceptsProtein tyrosine kinase activityKinase activityEGF receptorIntrinsic protein tyrosine kinase activityGrowth factor receptor protein tyrosine kinaseSrc homology 2 (SH2) regionsEpidermal growth factor receptor protein tyrosine kinaseEGF receptor protein tyrosine kinase activityReceptor protein tyrosine kinaseRegulatory phosphorylation sitesEGF-stimulated phosphorylationCalmodulin-dependent protein kinase IIProtein tyrosine kinasesEGF-stimulated endocytosisProtein kinase IICell surface receptorsEpidermal growth factor receptorPhosphorylation sitesBinding of EGFSignal transductionGrowth factor receptorCarboxyl terminusSer1046/7Kinase IIEGF treatment
1987
Nerve growth factor treatment or cAMP elevation reduces Ca2+/calmodulin-dependent protein kinase III activity in PC12 cells.
Nairn A, Nichols R, Brady M, Palfrey H. Nerve growth factor treatment or cAMP elevation reduces Ca2+/calmodulin-dependent protein kinase III activity in PC12 cells. Journal Of Biological Chemistry 1987, 262: 14265-14272. PMID: 2443502, DOI: 10.1016/s0021-9258(18)47933-1.Peer-Reviewed Original ResearchConceptsNerve growth factorEffect of forskolinIII activityPC12 cellsGrowth factorLong-term treatmentShort-term treatmentEffect of treatmentNerve growth factor treatmentGrowth factor treatmentAbility of forskolinAbility of NGFPhorbol esterEpidermal growth factorMaximal effectCytosolic extractsFactor treatmentForskolinCAMP elevationTreatmentCell linesProtein kinase CRemoval of forskolinImmunological techniquesDependent protein phosphorylationRapid activation of calmodulin-dependent protein kinase III in mitogen-stimulated human fibroblasts. Correlation with intracellular Ca2+ transients.
Palfrey H, Nairn A, Muldoon L, Villereal M. Rapid activation of calmodulin-dependent protein kinase III in mitogen-stimulated human fibroblasts. Correlation with intracellular Ca2+ transients. Journal Of Biological Chemistry 1987, 262: 9785-9792. PMID: 3496338, DOI: 10.1016/s0021-9258(18)48002-7.Peer-Reviewed Original Research