2020
Biochemical characterization of age‐related calcium‐cAMP‐PKA signaling dysregulation and its effect on tau pathology in rhesus monkey cortex
Leslie S, Datta D, Wang M, van Dyck C, Arnsten A, Nairn A. Biochemical characterization of age‐related calcium‐cAMP‐PKA signaling dysregulation and its effect on tau pathology in rhesus monkey cortex. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.042017.Peer-Reviewed Original ResearchTau pathologyAge-related dysregulationAlzheimer's diseaseIntracellular calciumTau phosphorylationRhesus monkeysRat primary cortical culturesHuman post-mortem samplesVulnerable brain regionsSporadic Alzheimer's diseaseAmyloid-beta plaquesPrimary cortical culturesMain pathological hallmarksRhesus monkey cortexTau neurofibrillary tanglesYears of ageEarly-onset formAge-related vulnerabilityDorsolateral prefrontal cortexAge-related changesMonkey DLPFCPost-mortem samplesAD pathologyAmyloid pathologyUnknown etiology
1995
EF2K Elongation factor-2 kinase (vertebrates) (CaM-dependent PK III)
Nairn A. EF2K Elongation factor-2 kinase (vertebrates) (CaM-dependent PK III). 1995, 135-136. DOI: 10.1016/b978-012324719-3/50031-5.Peer-Reviewed Original ResearchElongation factor 2EF-2 kinaseElongation factor 2 kinaseYeast EF-2Factor 2EF2KMammalian enzymeSDS-PAGE systemDependent regulationRabbit reticulocytesSubunit sizeExact functionReticulocyte enzymeDifferent isoformsPolypeptide chainProtein synthesisKinaseCell proliferationSame affinityGrowth factorEnzymeDependent inhibitionPhosphorylatesIntracellular calciumCa2