1996
Activation of a Calcium-Calmodulin-dependent Protein Kinase I Cascade in PC12 Cells*
Aletta J, Selbert M, Nairn A, Edelman A. Activation of a Calcium-Calmodulin-dependent Protein Kinase I Cascade in PC12 Cells*. Journal Of Biological Chemistry 1996, 271: 20930-20934. PMID: 8702851, DOI: 10.1074/jbc.271.34.20930.Peer-Reviewed Original ResearchConceptsCaM kinase IDependent protein kinase IKinase IProtein kinase IPC12 cellsIntracellular Ca2L-type voltage-dependent Ca2PC12 pheochromocytoma cellsBlockade of Ca2Cellular regulationBiphasic phosphorylationVoltage-dependent Ca2Depolarization-induced activationPhosphorylationCalcium-calmodulinActivity of Ca2Extracellular Ca2I activityAcute formPheochromocytoma cellsPrior depolarizationIntracellular phosphorylationCellsActivationCa2
1992
Phosphorylation of elongation factor 2 during Ca2+-mediated secretion from rat parotid acini
Hincke M, Nairn A. Phosphorylation of elongation factor 2 during Ca2+-mediated secretion from rat parotid acini. Biochemical Journal 1992, 282: 877-882. PMID: 1372803, PMCID: PMC1130869, DOI: 10.1042/bj2820877.Peer-Reviewed Original ResearchConceptsElongation factor 2Protein synthesisFactor 2Two-dimensional PAGECalmodulin-dependent phosphorylationRapid phosphorylationParotid acinar cellsMolecular mechanismsRat parotid cellsPhosphorylationPhorbol esterStimulation of secretionProteinParotid cellsAcinar cellsRat parotid aciniParotid aciniSpecific antiseraCellsCa2ImmunoprecipitationExtracellular Ca2SecretionStimulationInhibition