Featured Publications
EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics
Freed DM, Bessman NJ, Kiyatkin A, Salazar-Cavazos E, Byrne PO, Moore JO, Valley CC, Ferguson KM, Leahy DJ, Lidke DS, Lemmon MA. EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics. Cell 2017, 171: 683-695.e18. PMID: 28988771, PMCID: PMC5650921, DOI: 10.1016/j.cell.2017.09.017.Peer-Reviewed Original ResearchMeSH KeywordsCrystallography, X-RayEpigenEpiregulinErbB ReceptorsFluorescence Resonance Energy TransferHumansKineticsLigandsModels, MolecularProtein MultimerizationConceptsReceptor tyrosine kinasesEpidermal growth factor receptorEGFR ligandsEGFR extracellular regionG protein-coupled receptorsDifferent EGFR ligandsCellular programsDifferent activating ligandsEGFR dimersCell signalingGrowth factor receptorExtracellular regionDimeric conformationEGFR dimerizationNew therapeutic opportunitiesReceptor dimersTyrosine kinaseBreast cancer cellsDimerization strengthActivating ligandsFactor receptorCancer cellsEpigenTherapeutic opportunitiesBiased agonism
2000
Crystallographic structure and functional interpretation of the cytoplasmic domain of erythrocyte membrane band 3
Zhang D, Kiyatkin A, Bolin J, Low P. Crystallographic structure and functional interpretation of the cytoplasmic domain of erythrocyte membrane band 3. Blood 2000, 96: 2925-2933. PMID: 11049968, DOI: 10.1182/blood.v96.9.2925.Peer-Reviewed Original ResearchConceptsCytoplasmic domainPeripheral proteinsAnimal cell plasma membranesRed blood cell membraneProtein tyrosine kinasesGlyceraldehyde-3-phosphate dehydrogenaseErythrocyte membrane band 3Major conformational changesMajor organizing centersCell plasma membraneBand 3Membrane band 3Protein 4.2Dimerization armProtein networkPlasma membraneMultiple proteinsTyrosine kinaseProtein ligandsOrganizing centerConformational changesImproved structural definitionCell membraneProtein 4Protein
1995
Crystallization and preliminary X‐ray analysis of the cytoplasmic domain of human erythrocyte band 3
Kiyatkin A, Natarajan P, Munshi S, Minor W, Johnson J, Low P. Crystallization and preliminary X‐ray analysis of the cytoplasmic domain of human erythrocyte band 3. Proteins Structure Function And Bioinformatics 1995, 22: 293-297. PMID: 7479704, DOI: 10.1002/prot.340220312.Peer-Reviewed Original Research