Refinement of a DNA based Alzheimer disease epitope vaccine in rabbits
Ghochikyan A, Davtyan H, Petrushina I, Hovakimyan A, Movsesyan N, Davtyan A, Kiyatkin A, Cribbs D, Agadjanyan M. Refinement of a DNA based Alzheimer disease epitope vaccine in rabbits. Human Vaccines & Immunotherapeutics 2013, 9: 1002-1010. PMID: 23399748, PMCID: PMC3899134, DOI: 10.4161/hv.23875.Peer-Reviewed Original ResearchConceptsDNA epitope vaccineEpitope vaccineTh epitopesAlzheimer's diseaseStrong humoral immune responseHumoral immune responseB-cell epitopesΒ-amyloid peptideN-terminal aspartic acidDNA vaccinePoor immunogenicityAD therapyHuman β-amyloid peptideImmune responseAD casesBrain sectionsCell epitopesEfficacy studiesVaccineEx vivoRhesus monkeysImmunogenicityShort amyloidEpitopesRabbits