Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells
Aksamitiene E, Achanta S, Kolch W, Kholodenko BN, Hoek JB, Kiyatkin A. Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells. Cellular Signalling 2011, 23: 1794-1805. PMID: 21726627, PMCID: PMC3156300, DOI: 10.1016/j.cellsig.2011.06.014.Peer-Reviewed Original ResearchMeSH KeywordsBreastBreast NeoplasmsCell Line, TumorFemaleGene Expression Regulation, NeoplasticGene SilencingHumansImmunoprecipitationMitogen-Activated Protein KinasesP21-Activated KinasesPhosphatidylinositol 3-KinasesPhosphorylationProlactinProtein BindingProto-Oncogene Proteins c-aktReal-Time Polymerase Chain ReactionRNA, Small InterferingSignal TransductionTransfectionConceptsBreast cancer cellsExtracellular signal-regulated kinases ERK1PI3-kinase/Akt pathwayDistinct signal transduction pathwaysERK1/2 mitogen-activated protein kinasesRac/PAK pathwayCancer cellsMitogen-activated protein kinaseSignal transduction pathwaysKinase/AktPDK1/AktJAK/STATSiRNA-mediated suppressionMAPK/ERKJAK2/STAT5MAPK signaling pathwaysRegulatory circuitsFAK activityKinases ERK1PAK pathwaySrc familyProtein interactionsProtein kinaseTransduction pathwaysPhosphoinositide 3THE ROUTES OF ERK ACTIVATION IN PROLACTIN‐STIMULATED BREAST CANCER CELLS
Aksamitiene E, Achanta S, Kiyatkin A, Hoek J. THE ROUTES OF ERK ACTIVATION IN PROLACTIN‐STIMULATED BREAST CANCER CELLS. The FASEB Journal 2011, 25: 946.1-946.1. DOI: 10.1096/fasebj.25.1_supplement.946.1.Peer-Reviewed Original ResearchJanus kinase/signal transducerDistinct signal transduction pathwaysRac/PAK pathwayBreast cancer cellsKinase/signal transducerRas/mitogenSignal transduction pathwaysActivator of transcriptionKinase/AktTotal cell lysatesActivity of JAK2Cancer cellsPI3K/AktAdaptor proteinShc familyPAK pathwaySrc familyProtein kinaseTransduction pathwaysTyrosine phosphorylationC-RafPhosphoinositide 3Cancer cell proliferationSignal transducerMAPK signaling