Prostaglandin E2 Stimulates a Ca2+-dependent K+ Channel in Human Erythrocytes and Alters Cell Volume and Filterability*
Li Q, Jungmann V, Kiyatkin A, Low P. Prostaglandin E2 Stimulates a Ca2+-dependent K+ Channel in Human Erythrocytes and Alters Cell Volume and Filterability*. Journal Of Biological Chemistry 1996, 271: 18651-18656. PMID: 8702518, DOI: 10.1074/jbc.271.31.18651.Peer-Reviewed Original ResearchConceptsProstaglandin E2Red blood cellsRelease of PGE2Efflux pathwayGardos channel inhibitorGardos channel activationM. Prostaglandin E2PGE2 treatmentIntact red blood cellsHuman erythrocytesMean cell volumeChannel inhibitorsClot formationEffects of metabolitesCell shrinkageGardos channelHuman red blood cellsNa/K/2Cl cotransportBlood cellsOsmotic fragilityChannel activationRed cellsPossible involvementPlateletsCell volume