Detection of the active components of calf thymus nuclear proteins (TNP), histones that are binding with high affinity to HIV-1 envelope proteins and CD4 molecules.
Mamikonyan G, Kiyatkin A, Movsesyan N, Mkrtichyan M, Ghochikyan A, Petrushina I, Hwang J, Ichim T, Keledjian H, Agadjanyan M. Detection of the active components of calf thymus nuclear proteins (TNP), histones that are binding with high affinity to HIV-1 envelope proteins and CD4 molecules. Current HIV Research 2008, 6: 318-26. PMID: 18691030, DOI: 10.2174/157016208785132545.Peer-Reviewed Original ResearchConceptsCD4 moleculeHIV-1 receptors CD4HIV-1 envelope proteinHIV-1 patientsHIV-1 proteinsAnti-viral activityAIDS patientsClinical trialsImmune functionReceptor CD4CD4Viral entryHigh affinityEnvelope proteinPatientsViral moleculesGp120Active componentsMolecular mechanismsGel electrophoresisPossible mechanismImmunoaffinity chromatographyNuclear proteinsTandem mass spectrometryPlacebo