2019
A single‐center, open‐label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteers
Finnema SJ, Rossano S, Naganawa M, Henry S, Gao H, Pracitto R, Maguire RP, Mercier J, Kervyn S, Nicolas J, Klitgaard H, DeBruyn S, Otoul C, Martin P, Muglia P, Matuskey D, Nabulsi NB, Huang Y, Kaminski RM, Hannestad J, Stockis A, Carson RE. A single‐center, open‐label positron emission tomography study to evaluate brivaracetam and levetiracetam synaptic vesicle glycoprotein 2A binding in healthy volunteers. Epilepsia 2019, 60: 958-967. PMID: 30924924, PMCID: PMC6532410, DOI: 10.1111/epi.14701.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnticonvulsantsCarbon RadioisotopesFemaleHealthy VolunteersHumansInhibitory Concentration 50Injections, IntravenousLevetiracetamMagnetic Resonance ImagingMaleMembrane GlycoproteinsNerve Tissue ProteinsNeuroimagingPositron-Emission TomographyProtein BindingPyrrolidinonesConceptsSynaptic vesicle glycoprotein 2AIntravenous brivaracetamHours postdoseBrain penetrationHealthy volunteersDaily oral dosingPositron emission tomography studyFurther clinical studiesEmission tomography studiesPlasma concentration relationshipPositron emission tomography (PET) tracerEmission tomography tracerVivo animal studiesAcute seizuresAntiepileptic drugsTherapeutic dosesCohort 2Oral dosingCohort 1Clinical studiesCohort 3LevetiracetamAnimal studiesRelevant dosesBrivaracetam
2004
Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness
Bailer U, Price J, Meltzer C, Mathis C, Frank G, Weissfeld L, McConaha C, Henry S, Brooks-Achenbach S, Barbarich N, Kaye W. Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness. Neuropsychopharmacology 2004, 29: 1143-1155. PMID: 15054474, PMCID: PMC4301578, DOI: 10.1038/sj.npp.1300430.Peer-Reviewed Original ResearchConceptsControl womenAnorexia nervosaPositron emission tomographyBulimia nervosaBrain serotonin 2A (5-HT(2A)) receptorsMajor depressive disorder diagnosisDisturbances of appetiteLeft subgenual cingulateHealthy control womenDepressive disorder diagnosisEffects of malnutritionSerotonin 2A receptorRight occipital cortexLeft parietal cortexSubgenual cingulate regionsAN-BNReceptor antagonistNeuronal pathwaysSubgenual cingulateOccipital cortexHigh incidenceCingulate regionsParietal cortexCortical regionsEmission tomography