2024
Noninvasive quantification of [18F]SynVesT-1 binding using simplified reference tissue model 2
Naganawa M, Gallezot J, Li S, Nabulsi N, Henry S, Cai Z, Matuskey D, Huang Y, Carson R. Noninvasive quantification of [18F]SynVesT-1 binding using simplified reference tissue model 2. European Journal Of Nuclear Medicine And Molecular Imaging 2024, 52: 113-121. PMID: 39155309, DOI: 10.1007/s00259-024-06885-6.Peer-Reviewed Original ResearchPositron emission tomographyCentrum semiovaleReference regionPositron emission tomography scanTest-retest variabilityTest-retest reproducibilitySynaptic vesicle glycoprotein 2AOne-tissue compartmentArterial blood samplesRetest scansGold standardBrain uptakeEmission tomographyBlood samplesCerebellumNoninvasive quantificationSRTM2ConclusionOur findingsPopulation averageHealthy participantsMetabolite analysisScan timeBPNDSemiovaleSynaptic loss and its association with symptom severity in Parkinson’s disease
Holmes S, Honhar P, Tinaz S, Naganawa M, Hilmer A, Gallezot J, Dias M, Yang Y, Toyonaga T, Esterlis I, Mecca A, Van Dyck C, Henry S, Ropchan J, Nabulsi N, Louis E, Comley R, Finnema S, Carson R, Matuskey D. Synaptic loss and its association with symptom severity in Parkinson’s disease. Npj Parkinson's Disease 2024, 10: 42. PMID: 38402233, PMCID: PMC10894197, DOI: 10.1038/s41531-024-00655-9.Peer-Reviewed Original ResearchSynaptic density lossPositron emission tomographyBinds to synaptic vesicle glycoprotein 2AAssociated with symptom severityParkinson's diseaseHigh-resolution positron emission tomographySynaptic vesicle glycoprotein 2ADuration of illnessPositron emission tomography scanBrain perfusionIllness durationSymptom severitySeverity of symptomsHC groupSubstantia nigraSynaptic densityLiving brainPD individualsClinical insightsDensity lossPD patientsEmission tomographyBrainSynaptic lossSynapse loss
2019
In vivo 5-HT6 and 5-HT2A receptor availability in antipsychotic treated schizophrenia patients vs. unmedicated healthy humans measured with [11C]GSK215083 PET
Radhakrishnan R, Matuskey D, Nabulsi N, Gaiser E, Gallezot JD, Henry S, Planeta B, Lin SF, Ropchan J, Huang Y, Carson RE, D'Souza DC. In vivo 5-HT6 and 5-HT2A receptor availability in antipsychotic treated schizophrenia patients vs. unmedicated healthy humans measured with [11C]GSK215083 PET. Psychiatry Research Neuroimaging 2019, 295: 111007. PMID: 31760336, DOI: 10.1016/j.pscychresns.2019.111007.Peer-Reviewed Original ResearchConceptsHealthy male controlsPositron emission tomographyMultilinear analysis 1Antipsychotic treatmentLower BPFrontal cortexReceptor availabilityAge-matched healthy male controlsDifferent second-generation antipsychoticsSteady-state troughPeak serum levelsSecond-generation antipsychoticsPotential therapeutic targetMale patientsSerum levelsHealthy humansTherapeutic targetSchizophrenia patientsTime-activity curvesMale controlsCognitive impairmentEmission tomographyVentral striatumPatientsSchizophreniaSocial status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers
Matuskey D, Dias M, Naganawa M, Pittman B, Henry S, Li S, Gao H, Ropchan J, Nabulsi N, Carson RE, Huang Y. Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers. Neuropsychopharmacology 2019, 44: 1714-1719. PMID: 30928993, PMCID: PMC6785144, DOI: 10.1038/s41386-019-0379-7.Peer-Reviewed Original ResearchConceptsBody mass indexKappa-opioid receptorsPositron emission tomographyAgonist radiotracerKOR systemOpioid receptorsTime-activity curvesBarratt Simplified MeasureAnterior cingulate cortexArterial blood samplingMultilinear analysis-1 (MA1) methodPET imaging studiesKOR levelsMass indexPreclinical modelsFrontal cortexHealthy volunteersRegional time-activity curvesBlood samplingPET scansCingulate cortexImaging studiesEmission tomographyVentral striatumRegional volumes
2015
Preclinical to Clinical Translation of CNS Transporter Occupancy of TD-9855, a Novel Norepinephrine and Serotonin Reuptake Inhibitor
Smith J, Patil D, Daniels O, Ding YS, Gallezot JD, Henry S, Kim K, Kshirsagar S, Martin W, Obedencio G, Stangeland E, Tsuruda P, Williams W, Carson R, Patil. Preclinical to Clinical Translation of CNS Transporter Occupancy of TD-9855, a Novel Norepinephrine and Serotonin Reuptake Inhibitor. The International Journal Of Neuropsychopharmacology 2015, 18: pyu027. PMID: 25522383, PMCID: PMC4368888, DOI: 10.1093/ijnp/pyu027.Peer-Reviewed Original ResearchMeSH KeywordsAdultAniline CompoundsAnimalsBlood Chemical AnalysisBrainHalf-LifeHumansMagnetic Resonance ImagingMaleModels, BiologicalMorpholinesNeurotransmitter Uptake InhibitorsNorepinephrine Plasma Membrane Transport ProteinsPhenyl EthersPiperidinesPositron-Emission TomographyRadiopharmaceuticalsRats, Sprague-DawleyReboxetineSerotonin Plasma Membrane Transport ProteinsSpinal CordSulfidesConceptsReuptake inhibitorsPositron emission tomographyNorepinephrine transporterSerotonin transporterSerotonin reuptake inhibitorsSingle oral doseUnique clinical profileMonoamine reuptake inhibitorsFuture clinical evaluationRat spinal cordNET occupancySERT occupancyClinical profileOral dosePlasma levelsTransporter profilesClinical evaluationSpinal cordTransporter occupancyCNS penetrationHealthy malesPharmacodynamic modelingNorepinephrineEmission tomographyPET studies
2007
Serotonin transporter binding after recovery from eating disorders
Bailer U, Frank G, Henry S, Price J, Meltzer C, Becker C, Ziolko S, Mathis C, Wagner A, Barbarich-Marsteller N, Putnam K, Kaye W. Serotonin transporter binding after recovery from eating disorders. Psychopharmacology 2007, 195: 315-324. PMID: 17690869, DOI: 10.1007/s00213-007-0896-7.Peer-Reviewed Original ResearchConceptsAnorexia nervosaBulimia nervosaControl womenMethodsPositron emission tomographyHealthy control womenRestricting-type anorexia nervosaRationaleSeveral linesDorsal rapheDistribution volume valuesBP valuesFunction persistEmission tomographyDisorder subjectsResultsAfter correctionMultiple comparisonsTracer kinetic modelNervosaSpecific bindingAffective regulationExaggerated 5-HT1A but Normal 5-HT2A Receptor Activity in Individuals Ill with Anorexia Nervosa
Bailer U, Frank G, Henry S, Price J, Meltzer C, Mathis C, Wagner A, Thornton L, Hoge J, Ziolko S, Becker C, McConaha C, Kaye W. Exaggerated 5-HT1A but Normal 5-HT2A Receptor Activity in Individuals Ill with Anorexia Nervosa. Biological Psychiatry 2007, 61: 1090-1099. PMID: 17241616, DOI: 10.1016/j.biopsych.2006.07.018.Peer-Reviewed Original ResearchConceptsPositron emission tomographyILL ANCerebral blood flowControl womenAnorexia nervosaBlood flowReceptor activityOrbital frontal regionsDorsal raphe nucleusHealthy control womenLateral temporal lobeReceptor-specific radioligandReceptor BPRaphe nucleusPoor responseSerotonin activityTemporal lobeParietal cortexEmission tomographyReceptor functionParietal regionsWomenReceptorsFrontal regionsSignificant increase
2005
Altered Brain Serotonin 5-HT1A Receptor Binding After Recovery From Anorexia Nervosa Measured by Positron Emission Tomography and [Carbonyl11C]WAY-100635
Bailer U, Frank G, Henry S, Price J, Meltzer C, Weissfeld L, Mathis C, Drevets W, Wagner A, Hoge J, Ziolko S, McConaha C, Kaye W. Altered Brain Serotonin 5-HT1A Receptor Binding After Recovery From Anorexia Nervosa Measured by Positron Emission Tomography and [Carbonyl11C]WAY-100635. JAMA Psychiatry 2005, 62: 1032-1041. PMID: 16143735, DOI: 10.1001/archpsyc.62.9.1032.Peer-Reviewed Original ResearchConceptsRestricting-type anorexia nervosaPositron emission tomographyAnorexia nervosaReceptor bindingEmission tomographyControl womenPathogenesis of ANDistribution volumeHealthy control womenEffects of malnutritionSerotonin neuronal activityLogan graphical methodPrefrontal cortical regionsSubgenual cingulate regionsBrain serotoninDorsal rapheReceptor antagonistSerotonergic functionBody of evidenceNeuronal activityCingulate regionsReceptor activityCortical regionsMeasures of anxietyWomenBrain imaging of serotonin after recovery from anorexia and bulimia nervosa
Kaye W, Bailer U, Frank G, Wagner A, Henry S. Brain imaging of serotonin after recovery from anorexia and bulimia nervosa. Physiology & Behavior 2005, 86: 15-17. PMID: 16102788, DOI: 10.1016/j.physbeh.2005.06.019.Peer-Reviewed Original ResearchConceptsBulimia nervosaPositron emission tomographyAnorexia nervosaReceptor functionModulation of feedingAge of onsetDegree of efficacyHomogenous presentationSerotonin pathwayGender distributionEmission tomographyBody image distortionBrain functionNew pharmacologyBrain imagingParietal regionsNervosaFood consumptionLines of evidenceSymptomsIllnessAlterationsPsychotherapy approachesPathwayFeeding behaviorIncreased Dopamine D2/D3 Receptor Binding After Recovery from Anorexia Nervosa Measured by Positron Emission Tomography and [11C]Raclopride
Frank G, Bailer U, Henry S, Drevets W, Meltzer C, Price J, Mathis C, Wagner A, Hoge J, Ziolko S, Barbarich-Marsteller N, Weissfeld L, Kaye W. Increased Dopamine D2/D3 Receptor Binding After Recovery from Anorexia Nervosa Measured by Positron Emission Tomography and [11C]Raclopride. Biological Psychiatry 2005, 58: 908-912. PMID: 15992780, DOI: 10.1016/j.biopsych.2005.05.003.Peer-Reviewed Original ResearchConceptsD2/D3 receptor bindingD3 receptor bindingControl womenAnorexia nervosaPositron emission tomographyDopamine D2/D3 receptor bindingD2/D3 receptor densityEmission tomographyReceptor bindingREC ANHealthy control womenD3 receptor densityEffects of malnutritionDorsal putamenAlterations of weightDorsal caudatePhysical activityReceptor densityDopamine functionMotor activityDA concentrationLines of evidenceWomenNervosaTomography
2004
Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness
Bailer U, Price J, Meltzer C, Mathis C, Frank G, Weissfeld L, McConaha C, Henry S, Brooks-Achenbach S, Barbarich N, Kaye W. Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness. Neuropsychopharmacology 2004, 29: 1143-1155. PMID: 15054474, PMCID: PMC4301578, DOI: 10.1038/sj.npp.1300430.Peer-Reviewed Original ResearchConceptsControl womenAnorexia nervosaPositron emission tomographyBulimia nervosaBrain serotonin 2A (5-HT(2A)) receptorsMajor depressive disorder diagnosisDisturbances of appetiteLeft subgenual cingulateHealthy control womenDepressive disorder diagnosisEffects of malnutritionSerotonin 2A receptorRight occipital cortexLeft parietal cortexSubgenual cingulate regionsAN-BNReceptor antagonistNeuronal pathwaysSubgenual cingulateOccipital cortexHigh incidenceCingulate regionsParietal cortexCortical regionsEmission tomography