2021
A comparison of two hybrid closed-loop systems in adolescents and young adults with type 1 diabetes (FLAIR): a multicentre, randomised, crossover trial
Bergenstal RM, Nimri R, Beck RW, Criego A, Laffel L, Schatz D, Battelino T, Danne T, Weinzimer SA, Sibayan J, Johnson ML, Bailey RJ, Calhoun P, Carlson A, Isganaitis E, Bello R, Albanese-O'Neill A, Dovc K, Biester T, Weyman K, Hood K, Phillip M, Group F. A comparison of two hybrid closed-loop systems in adolescents and young adults with type 1 diabetes (FLAIR): a multicentre, randomised, crossover trial. The Lancet 2021, 397: 208-219. PMID: 33453783, PMCID: PMC9194961, DOI: 10.1016/s0140-6736(20)32514-9.Peer-Reviewed Original ResearchConceptsAdvanced hybrid closed-loop systemType 1 diabetesHybrid closed-loop systemMiniMed 670G systemGlucose levelsCrossover trialYoung adultsMultiple daily insulin injectionsSevere hypoglycaemic eventsDaily insulin injectionsComputer-generated sequencePermuted block designContinuous glucose monitoringBaseline HbACoprimary outcomesEndocrinology practiceHypoglycaemic eventsWashout periodHemoglobin levelsKidney diseaseMean ageInsulin injectionsProportion of timeContinuous glucose monitorImpaired awareness
2018
Optimizing Hybrid Closed-Loop Therapy in Adolescents and Emerging Adults Using the MiniMed 670G System
Messer LH, Forlenza GP, Sherr JL, Wadwa RP, Buckingham BA, Weinzimer SA, Maahs DM, Slover RH. Optimizing Hybrid Closed-Loop Therapy in Adolescents and Emerging Adults Using the MiniMed 670G System. Diabetes Care 2018, 41: dc171682. PMID: 29444895, PMCID: PMC6463622, DOI: 10.2337/dc17-1682.Peer-Reviewed Original ResearchConceptsMiniMed 670G systemHybrid closed-loop therapyTotal daily insulin doseYoung adult participantsDaily insulin doseType 1 diabetesOptimal clinical useAdult participantsClosed-loop therapyHybrid closed-loop systemPivotal trialsYounger patientsInsulin doseInsulin ratioClinical guidancePercentage of timeHCL useClinical sitesClinical useMonthsStudy phaseTrialsUse ratesParticipantsDelivery patterns