2021
Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study.
Mauras N, Buckingham B, White NH, Tsalikian E, Weinzimer SA, Jo B, Cato A, Fox LA, Aye T, Arbelaez AM, Hershey T, Tansey M, Tamborlane W, Foland-Ross LC, Shen H, Englert K, Mazaika P, Marzelli M, Reiss AL. Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study. Diabetes Care 2021, 44: 983-992. PMID: 33568403, PMCID: PMC7985430, DOI: 10.2337/dc20-2125.Peer-Reviewed Original ResearchConceptsType 1 diabetesBrain volumeControl subjectsTotal brain volume differencesEarly-onset type 1 diabetesAge-matched control subjectsIntelligence quotientCognitive scoresWhite matter volumeBrain volume differencesContinuous glucose monitoringDiabetes groupFull-scale intelligence quotientDiabetes complicationsDiabetes controlTotal brainVerbal intelligence quotientDiabetesMatter volumeSensor glucoseCognitive testingGlucose monitoringMixed-effects modelsBrainGroup differences
2016
Compensatory Hyperconnectivity in Developing Brains of Young Children With Type 1 Diabetes
Saggar M, Tsalikian E, Mauras N, Mazaika P, White NH, Weinzimer S, Buckingham B, Hershey T, Reiss AL. Compensatory Hyperconnectivity in Developing Brains of Young Children With Type 1 Diabetes. Diabetes 2016, 66: 754-762. PMID: 27702833, PMCID: PMC5319714, DOI: 10.2337/db16-0414.Peer-Reviewed Original ResearchConceptsControl subjectsIntrinsic connectivityAge-matched control subjectsYoung childrenBrain intrinsic connectivityResting-state functional MRI dataType 1 diabetesSeed-based analysisCognitive functioningBlood glucoseSustained dysregulationOverall group differencesLarge multisite studyT1DYounger ageFunctional MRI dataCognitive deficitsType 1Cognitive functionObserved positive associationDiabetesMultisite studyCompensatory roleGroup differencesBrain