2022
Mechanistic Insights Into the Heterogeneity of Glucose Response Classes in Youths With Obesity: A Latent Class Trajectory Approach
Tricò D, McCollum S, Samuels S, Santoro N, Galderisi A, Groop L, Caprio S, Shabanova V. Mechanistic Insights Into the Heterogeneity of Glucose Response Classes in Youths With Obesity: A Latent Class Trajectory Approach. Diabetes Care 2022, 45: 1841-1851. PMID: 35766976, PMCID: PMC9346992, DOI: 10.2337/dc22-0110.Peer-Reviewed Original ResearchConceptsOral glucose tolerance testΒ-cell functionΒ-cell glucose sensitivityInsulin sensitivityGenetic risk profileMultiple oral glucose tolerance testsDifferent genetic risk profilesRisk profileMin oral glucose tolerance testLatent class trajectory analysisGlucose tolerance testImpaired insulin sensitivityPlasma glucose responseGlucose sensitivityClass 3Model-predicted probabilityClass 1Tolerance testProgressive impairmentMultiethnic cohortGlucose responseLongitudinal changesObesityTransient reductionInsulin kinetics342-OR: Low Incretin Effect Is Associated with Longitudinal Decline of Beta-Cell Function and Insulin Sensitivity in Obese Youth
GALDERISI A, LAT J, SAMUELS S, PIERPONT B, VAN NAME M, SANTORO N, CAPRIO S. 342-OR: Low Incretin Effect Is Associated with Longitudinal Decline of Beta-Cell Function and Insulin Sensitivity in Obese Youth. Diabetes 2022, 71 DOI: 10.2337/db22-342-or.Peer-Reviewed Original ResearchBeta-cell functionIncretin effectInsulin sensitivityInsulin secretionCell functionFirst-phase insulin secretionIsoglycemic intravenous glucose infusionLongitudinal declineReduced β-cell functionEarly insulin secretionLower insulin sensitivityIntravenous glucose infusionΒ-cell functionOral minimal modelIncretin groupsObese youthGlucose infusionRelative increaseNational InstituteTertileLongitudinal trajectoriesObesitySecretionGlucoseGroup
2021
The Yale Bright Bodies Lifestyle Intervention Program: An Intensive Lifestyle Intervention for Obese Children and Adolescents With and Without T2D
Savoye M, Rose P, Samuels S, Tamborlane W, Caprio S, Van Name M. The Yale Bright Bodies Lifestyle Intervention Program: An Intensive Lifestyle Intervention for Obese Children and Adolescents With and Without T2D. Contemporary Endocrinology 2021, 203-216. DOI: 10.1007/978-3-030-64133-7_19.ChaptersLifestyle intervention programLifestyle interventionObese childrenIntensive lifestyle intervention programPediatric lifestyle interventionCornerstone of treatmentIntensive lifestyle interventionPrevalence of obesityType 2 diabetesIntervention programsOverproduction of insulinInsulin sensitivityClinical studiesBody weightCaregiver supportT2DChildrenInterventionPrevalenceAdolescentsGlycemiaObesityDiabetesT2D.Dietitians