2024
Development of a Marmoset Apparatus for Automated Pulling to study cooperative behaviors
Meisner O, Shi W, Fagan N, Greenwood J, Jadi M, Nandy A, Chang S. Development of a Marmoset Apparatus for Automated Pulling to study cooperative behaviors. ELife 2024, 13 DOI: 10.7554/elife.97088.3.Peer-Reviewed Original ResearchDevelopment of a Marmoset Apparatus for Automated Pulling to study cooperative behaviors
Meisner O, Shi W, Fagan N, Greenwood J, Jadi M, Nandy A, Chang S. Development of a Marmoset Apparatus for Automated Pulling to study cooperative behaviors. ELife 2024, 13: rp97088. PMID: 39466838, PMCID: PMC11517257, DOI: 10.7554/elife.97088.Peer-Reviewed Original ResearchSpatial context non-uniformly modulates inter-laminar information flow in the primary visual cortex
Xu X, Morton M, Denagamage S, Hudson N, Nandy A, Jadi M. Spatial context non-uniformly modulates inter-laminar information flow in the primary visual cortex. Neuron 2024 PMID: 39442514, DOI: 10.1016/j.neuron.2024.09.021.Peer-Reviewed Original ResearchPrimary visual cortexVisual cortexInformation flowCommunication subspaceDimensionality reduction approachSensory hierarchyOrganization of objectsOutput layerSpatial organization of objectsInformation propagationPerceptual degradationCortical connectivityEffective feedback signalActivity of neuronal ensemblesContextual signalsInfluence information flowSpatial configurationNeuronal ensemblesNon-uniformityConfigurationReduction approachPredictive Remapping in Neural Networks: A Model Based on Corollary Discharge Signals for Visual Continuity Across Saccades
Nandy A, Xu X, Jadi M. Predictive Remapping in Neural Networks: A Model Based on Corollary Discharge Signals for Visual Continuity Across Saccades. Journal Of Vision 2024, 24: 1401. DOI: 10.1167/jov.24.10.1401.Peer-Reviewed Original ResearchSpatial configuration of contextual stimuli influences inter-laminar interactions in macaque primary visual cortex
Xu X, Morton M, Hudson N, Nandy A, Jadi M. Spatial configuration of contextual stimuli influences inter-laminar interactions in macaque primary visual cortex. Journal Of Vision 2024, 24: 338. DOI: 10.1167/jov.24.10.338.Peer-Reviewed Original ResearchCorrigendum to “The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors” [Neurobiol. Learn. Mem. 203 (2023) 107793]
Shi W, Meisner O, Blackmore S, Jadi M, Nandy A, Chang S. Corrigendum to “The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors” [Neurobiol. Learn. Mem. 203 (2023) 107793]. Neurobiology Of Learning And Memory 2024, 214: 107973. PMID: 39174377, PMCID: PMC11426288, DOI: 10.1016/j.nlm.2024.107973.Peer-Reviewed Original ResearchBrain-state mediated modulation of inter-laminar dependencies in visual cortex
Das A, Sheffield A, Nandy A, Jadi M. Brain-state mediated modulation of inter-laminar dependencies in visual cortex. Nature Communications 2024, 15: 5105. PMID: 38877026, PMCID: PMC11178935, DOI: 10.1038/s41467-024-49144-w.Peer-Reviewed Original ResearchConceptsBrain state fluctuationsUnique dependenceSpatial attentionBehavioral outcomesState fluctuationsDeployment of spatial attentionDeployment of attentionBehaviorally relevant objectsComputational goalCluttered environmentsVisual cortexObject recognitionExcitatory populationHierarchical computationVisual area V4Internal fluctuationsDependenceRelevant objectsModulation patternsTask demandsEnhance information transferCortical networksNeural activityInformation transferArea V4
2023
The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors
Shi W, Meisner O, Blackmore S, Jadi M, Nandy A, Chang S. The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors. Neurobiology Of Learning And Memory 2023, 203: 107793. PMID: 37353191, PMCID: PMC10527225, DOI: 10.1016/j.nlm.2023.107793.Peer-Reviewed Original ResearchConceptsOrbitofrontal cortexOFC functionCognitive mapsOFC neuronsNon-social domainCore brain areasNon-social behaviorsReward-based behaviorsValues-based behaviorSocial behaviorSocial contextBrain areasBehavioral contextSocial functionComplex representationSingle subjectCortexBehaviorTremendous knowledgeIntegrated viewContextTask spaceMAP frameworkRepresentationWide array
2020
Correction: Optogenetically induced low-frequency correlations impair perception
Nandy AS, Nassi JJ, Jadi MP, Reynolds JH. Correction: Optogenetically induced low-frequency correlations impair perception. ELife 2020, 9: e55718. PMID: 32658639, PMCID: PMC7358006, DOI: 10.7554/elife.55718.Peer-Reviewed Original Research
2019
Optogenetically induced low-frequency correlations impair perception
Nandy A, Nassi JJ, Jadi MP, Reynolds J. Optogenetically induced low-frequency correlations impair perception. ELife 2019, 8: e35123. PMID: 30794156, PMCID: PMC6391072, DOI: 10.7554/elife.35123.Peer-Reviewed Original Research
2017
Cortical gamma band synchronization through somatostatin interneurons
Veit J, Hakim R, Jadi MP, Sejnowski TJ, Adesnik H. Cortical gamma band synchronization through somatostatin interneurons. Nature Neuroscience 2017, 20: 951-959. PMID: 28481348, PMCID: PMC5511041, DOI: 10.1038/nn.4562.Peer-Reviewed Original Research
2016
Modulatory compartments in cortex and local regulation of cholinergic tone
Coppola JJ, Ward NJ, Jadi MP, Disney AA. Modulatory compartments in cortex and local regulation of cholinergic tone. Journal Of Physiology-Paris 2016, 110: 3-9. PMID: 27553093, PMCID: PMC5164978, DOI: 10.1016/j.jphysparis.2016.08.001.Peer-Reviewed Original ResearchConceptsCholinergic modulationCortical circuitsLocal cortical circuitsSubcellular receptor localizationCholinergic toneCholinergic systemReceptor expressionAxonal innervationModulatory inputsVisual pathwayLocal circuitsCortical tissueNeuromodulatory signalingReceptor localizationNeuromodulatory toneCortexPathological statesLocal regulationModulatory signalsExistence of compartmentsCompartmentsToneSpecific responsesSignalingInnervationNeurons in Macaque Area V4 Are Tuned for Complex Spatio-Temporal Patterns
Nandy AS, Mitchell JF, Jadi MP, Reynolds JH. Neurons in Macaque Area V4 Are Tuned for Complex Spatio-Temporal Patterns. Neuron 2016, 91: 920-930. PMID: 27499085, PMCID: PMC4990477, DOI: 10.1016/j.neuron.2016.07.026.Peer-Reviewed Original Research
2015
Abnormal Gamma Oscillations in N-Methyl-D-Aspartate Receptor Hypofunction Models of Schizophrenia
Jadi MP, Behrens MM, Sejnowski TJ. Abnormal Gamma Oscillations in N-Methyl-D-Aspartate Receptor Hypofunction Models of Schizophrenia. Biological Psychiatry 2015, 79: 716-726. PMID: 26281716, PMCID: PMC4720598, DOI: 10.1016/j.biopsych.2015.07.005.Peer-Reviewed Original ResearchConceptsInhibitory neuronsGamma-band oscillationsNMDAR hypofunctionAnimal modelsN-methyl-D-aspartate (NMDA) receptor hypofunctionParvalbumin-expressing inhibitory neuronsAbnormal gamma oscillationsReceptor hypofunctionNMDAR antagonistsHypofunctionVisual cortexSZ symptomsSchizophreniaGamma oscillationsGenetic knockoutHuman subjectsBand oscillationsSymptomsNeuronsMagnetoencephalography (MEG) signalsPatientsAntagonistN-methylCortexNeuropharmacology
2014
An Augmented Two-Layer Model Captures Nonlinear Analog Spatial Integration Effects in Pyramidal Neuron Dendrites
Jadi MP, Behabadi BF, Poleg-Polsky A, Schiller J, Mel BW. An Augmented Two-Layer Model Captures Nonlinear Analog Spatial Integration Effects in Pyramidal Neuron Dendrites. Proceedings Of The IEEE 2014, 102: 782-798. PMID: 25554708, PMCID: PMC4279447, DOI: 10.1109/jproc.2014.2312671.Peer-Reviewed Original ResearchRegulating Cortical Oscillations in an Inhibition-Stabilized Network
Jadi MP, Sejnowski TJ. Regulating Cortical Oscillations in an Inhibition-Stabilized Network. Proceedings Of The IEEE 2014, 102: 830-842. PMID: 24966414, PMCID: PMC4067313, DOI: 10.1109/jproc.2014.2313113.Peer-Reviewed Original ResearchCortical oscillations arise from contextual interactions that regulate sparse coding
Jadi MP, Sejnowski TJ. Cortical oscillations arise from contextual interactions that regulate sparse coding. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 6780-6785. PMID: 24742427, PMCID: PMC4020078, DOI: 10.1073/pnas.1405300111.Peer-Reviewed Original ResearchConceptsInhibitory neuronsFiring ratePower of oscillationsMonosynaptic inputDisynaptic pathwayHigher firing ratesLow firing ratesDisynaptic inputCortical circuitsSynaptic plasticityCortical stateCortical oscillationsModel cortical circuitSensory stimuliBehavioral statesStimulationSensory inputComplex natural stimuliInhibitory controlCortexNeuronsSpike timingActivity balanceNatural stimuliParadoxical experimental findings
2012
Location-Dependent Excitatory Synaptic Interactions in Pyramidal Neuron Dendrites
Behabadi BF, Polsky A, Jadi M, Schiller J, Mel BW. Location-Dependent Excitatory Synaptic Interactions in Pyramidal Neuron Dendrites. PLOS Computational Biology 2012, 8: e1002599. PMID: 22829759, PMCID: PMC3400572, DOI: 10.1371/journal.pcbi.1002599.Peer-Reviewed Original ResearchConceptsExcitatory synaptic contactsPyramidal neuronsSynaptic contactsSpike thresholdExcitatory synaptic interactionsBasal dendritic arborsNeocortical pyramidal neuronsMore proximal inputsBasal dendritesExcitatory pathwaysDendritic arborsDistal excitationBrain slicesSynaptic projectionsSynaptic interactionsElectrophysiological recordingsProximal inputsResponse modulationFunctional asymmetryNeuronsPeak responseSomaDistal endPN responsesDendritesLocation-Dependent Effects of Inhibition on Local Spiking in Pyramidal Neuron Dendrites
Jadi M, Polsky A, Schiller J, Mel BW. Location-Dependent Effects of Inhibition on Local Spiking in Pyramidal Neuron Dendrites. PLOS Computational Biology 2012, 8: e1002550. PMID: 22719240, PMCID: PMC3375251, DOI: 10.1371/journal.pcbi.1002550.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsCalcium SignalingComputational BiologyComputer SimulationDendritesExcitatory Postsynaptic PotentialsGamma-Aminobutyric AcidIn Vitro TechniquesMaleModels, NeurologicalN-MethylaspartatePyramidal CellsRatsRats, WistarSomatosensory CortexConceptsPyramidal neuronsDendritic inhibitionInterneuron typesDendritic spikesLayer 5 pyramidal neuronsSpike thresholdDistal dendritic inhibitionInhibitory interneuron typesSpike initiation zoneDendritic spike thresholdDifferent neural pathwaysBasal dendritesSynaptic contactsNeocortical slicesCortical circuitsDendritic responsesNeural pathwaysSomatic inhibitionLocal spikingSpike generationCortical computationRelative activationInhibitionDetailed compartmental modelNeurons