2015
Abnormal Gamma Oscillations in N-Methyl-D-Aspartate Receptor Hypofunction Models of Schizophrenia
Jadi MP, Behrens MM, Sejnowski TJ. Abnormal Gamma Oscillations in N-Methyl-D-Aspartate Receptor Hypofunction Models of Schizophrenia. Biological Psychiatry 2015, 79: 716-726. PMID: 26281716, PMCID: PMC4720598, DOI: 10.1016/j.biopsych.2015.07.005.Peer-Reviewed Original ResearchConceptsInhibitory neuronsGamma-band oscillationsNMDAR hypofunctionAnimal modelsN-methyl-D-aspartate (NMDA) receptor hypofunctionParvalbumin-expressing inhibitory neuronsAbnormal gamma oscillationsReceptor hypofunctionNMDAR antagonistsHypofunctionVisual cortexSZ symptomsSchizophreniaGamma oscillationsGenetic knockoutHuman subjectsBand oscillationsSymptomsNeuronsMagnetoencephalography (MEG) signalsPatientsAntagonistN-methylCortexNeuropharmacology
2012
Location-Dependent Effects of Inhibition on Local Spiking in Pyramidal Neuron Dendrites
Jadi M, Polsky A, Schiller J, Mel BW. Location-Dependent Effects of Inhibition on Local Spiking in Pyramidal Neuron Dendrites. PLOS Computational Biology 2012, 8: e1002550. PMID: 22719240, PMCID: PMC3375251, DOI: 10.1371/journal.pcbi.1002550.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsCalcium SignalingComputational BiologyComputer SimulationDendritesExcitatory Postsynaptic PotentialsGamma-Aminobutyric AcidIn Vitro TechniquesMaleModels, NeurologicalN-MethylaspartatePyramidal CellsRatsRats, WistarSomatosensory CortexConceptsPyramidal neuronsDendritic inhibitionInterneuron typesDendritic spikesLayer 5 pyramidal neuronsSpike thresholdDistal dendritic inhibitionInhibitory interneuron typesSpike initiation zoneDendritic spike thresholdDifferent neural pathwaysBasal dendritesSynaptic contactsNeocortical slicesCortical circuitsDendritic responsesNeural pathwaysSomatic inhibitionLocal spikingSpike generationCortical computationRelative activationInhibitionDetailed compartmental modelNeurons