Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsMei-Ling Yang, PhD
Assistant Professor AdjunctAbout
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Titles
Assistant Professor Adjunct
Biography
Dr. Mei-Ling Yang is Assistant Professor Adjunct for Rheumatology, Allergy & Immunology at Yale University School of Medicine. She obtained her PhD degree in Biochemistry and Molecular Biology at National Taiwan University at 2002 and then joined the laboratory of Dr. Mark Mamula for her postdoctoral training. She studied the role of protein modifications in lupus autoimmunity under Arthritis Foundation Postdoctoral Fellowship. Dr. Yang became part of the faculty in 2008 and current research focus is to understand how inflammation and posttranslational modifications evoke autoimmune responses in type 1 diabetes and systemic lupus erythematosus.
Appointments
Rheumatology
Assistant Professor AdjunctPrimary
Other Departments & Organizations
Education & Training
- PhD
- National Taiwan Univ (2002)
- BS
- National Taiwan Univ (1993)
Research
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Overview
Post-translational protein modification influences immunologic responses ranging from intracellular signaling to protein processing and presentation and creates neo-epitopes from self-proteins to break immune tolerance that leads to autoimmune diseases. Systemic erythematosus lupus (SLE) and type 1 diabetes (T1D) are the complex autoimmune diseases involving multiple genetic and environmental factors. My research is to investigate the role of posttranslational protein modifications including isoaspartyl modification, methylation, carbonylation and citrullination on genetic association analysis and biological functions of T cells in the pathogenesis of SLE and T1D. My work provides new insight into the diagnosis of autoimmune diseases where the specific auto-antigen is unknown and provides targets in autoimmune pathways to discover novel therapeutic concepts and biomarkers for inflammatory conditions.
Medical Research Interests
ORCID
0000-0003-1687-2463
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Mark Mamula, PhD
TuKiet Lam, PhD, BS
Ana Luisa Perdigoto, MD, PhD
Hester Doyle, PhD
Richard Kibbey, MD, PhD
Harriet Kluger, MD
Diabetes Mellitus, Type 1
Autoimmune Diseases
Lupus Erythematosus, Systemic
Publications
2023
Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus
Yang M, Lam T, Kanyo J, Kang I, Zhou Z, Clarke S, Mamula M. Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus. Autoimmunity 2023, 56: 2282945. PMID: 37994408, PMCID: PMC10897934, DOI: 10.1080/08916934.2023.2282945.Peer-Reviewed Original ResearchCitationsAltmetric
2022
A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes
Syed F, Singhal D, Raedschelders K, Krishnan P, Bone R, McLaughlin M, Van Eyk J, Mirmira R, Yang M, Mamula M, Wu H, Liu X, Evans-Molina C. A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes. EBioMedicine 2022, 87: 104379. PMID: 36463755, PMCID: PMC9719098, DOI: 10.1016/j.ebiom.2022.104379.Peer-Reviewed Original ResearchCitationsAltmetricBiomarkers of autoimmunity and beta cell metabolism in type 1 diabetes
Yang M, Kibbey R, Mamula M. Biomarkers of autoimmunity and beta cell metabolism in type 1 diabetes. Frontiers In Immunology 2022, 13: 1028130. PMID: 36389721, PMCID: PMC9647083, DOI: 10.3389/fimmu.2022.1028130.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricImmune cells and their inflammatory mediators modify beta cells and cause checkpoint inhibitor-induced diabetes
Perdigoto AL, Deng S, Du KC, Kuchroo M, Burkhardt DB, Tong A, Israel G, Robert ME, Weisberg SP, Kirkiles-Smith N, Stamatouli AM, Kluger HM, Quandt Z, Young A, Yang ML, Mamula MJ, Pober JS, Anderson MS, Krishnaswamy S, Herold KC. Immune cells and their inflammatory mediators modify beta cells and cause checkpoint inhibitor-induced diabetes. JCI Insight 2022, 7: e156330. PMID: 35925682, PMCID: PMC9536276, DOI: 10.1172/jci.insight.156330.Peer-Reviewed Original ResearchCitationsAltmetricCarbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity.
Yang ML, Connolly SE, Gee RJ, Lam TT, Kanyo J, Peng J, Guyer P, Syed F, Tse HM, Clarke SG, Clarke CF, James EA, Speake C, Evans-Molina C, Arvan P, Herold KC, Wen L, Mamula MJ. Carbonyl Posttranslational Modification Associated With Early-Onset Type 1 Diabetes Autoimmunity. Diabetes 2022, 71: 1979-1993. PMID: 35730902, PMCID: PMC9450849, DOI: 10.2337/db21-0989.Peer-Reviewed Original ResearchCitationsCitrullination of glucokinase is linked to autoimmune diabetes
Yang ML, Horstman S, Gee R, Guyer P, Lam TT, Kanyo J, Perdigoto AL, Speake C, Greenbaum CJ, Callebaut A, Overbergh L, Kibbey RG, Herold KC, James EA, Mamula MJ. Citrullination of glucokinase is linked to autoimmune diabetes. Nature Communications 2022, 13: 1870. PMID: 35388005, PMCID: PMC8986778, DOI: 10.1038/s41467-022-29512-0.Peer-Reviewed Original ResearchCitationsAltmetric
2021
Citrullination and PAD Enzyme Biology in Type 1 Diabetes – Regulators of Inflammation, Autoimmunity, and Pathology
Yang ML, Sodré FMC, Mamula MJ, Overbergh L. Citrullination and PAD Enzyme Biology in Type 1 Diabetes – Regulators of Inflammation, Autoimmunity, and Pathology. Frontiers In Immunology 2021, 12: 678953. PMID: 34140951, PMCID: PMC8204103, DOI: 10.3389/fimmu.2021.678953.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2018
Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes
Buitinga M, Callebaut A, Sodré F, Crèvecoeur I, Blahnik-Fagan G, Yang ML, Bugliani M, Arribas-Layton D, Marré M, Cook DP, Waelkens E, Mallone R, Piganelli JD, Marchetti P, Mamula MJ, Derua R, James EA, Mathieu C, Overbergh L. Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes. Diabetes 2018, 67: 2337-2348. PMID: 30348823, PMCID: PMC6973547, DOI: 10.2337/db18-0295.Peer-Reviewed Original ResearchCitationsAltmetricOxidative Modifications in Tissue Pathology and Autoimmune Disease
Yang ML, Doyle H, Clarke SG, Herold K, Mamula M. Oxidative Modifications in Tissue Pathology and Autoimmune Disease. Antioxidants & Redox Signaling 2018, 29: 1415-1431. PMID: 29088923, PMCID: PMC6166690, DOI: 10.1089/ars.2017.7382.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2016
The role for neutrophil extracellular traps in cystic fibrosis autoimmunity
Skopelja S, Hamilton BJ, Jones JD, Yang ML, Mamula M, Ashare A, Gifford AH, Rigby WF. The role for neutrophil extracellular traps in cystic fibrosis autoimmunity. JCI Insight 2016, 1: e88912. PMID: 27777975, PMCID: PMC5070963, DOI: 10.1172/jci.insight.88912.Peer-Reviewed Original ResearchCitationsAltmetric
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