2000
Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains
Morel L, Croker B, Blenman K, Mohan C, Huang G, Gilkeson G, Wakeland E. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proceedings Of The National Academy Of Sciences Of The United States Of America 2000, 97: 6670-6675. PMID: 10841565, PMCID: PMC18697, DOI: 10.1073/pnas.97.12.6670.Peer-Reviewed Original ResearchConceptsLoss of toleranceSystemic autoimmunityLupus-prone NZM2410 mouseFull disease expressionSevere systemic autoimmunitySystemic lupus erythematosusLupus-prone strainsLupus susceptibility genesFatal glomerulonephritisFatal lupusSevere glomerulonephritisLupus erythematosusKidney failureT cellsMurine strainsC57BL/6 backgroundB cellsAutoimmune phenotypeDisease pathogenesisNZM2410 miceTherapeutic interventionsFatal diseaseDisease expressionCongenic dissectionNuclear antigen
1996
Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain
Morel L, Yu Y, Blenman KR, Caldwell RA, Wakeland EK. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. Mammalian Genome 1996, 7: 335-339. PMID: 8661718, DOI: 10.1007/s003359900098.Peer-Reviewed Original ResearchConceptsGenomic intervalsSLE susceptibility genesSingle genomic intervalComplex polygenic traitCongenic strainsSLE susceptibility lociGenetic interactionsPositional cloningPolygenic traitGenetic crossesInterval mappingPhenotypic dataGenetic analysisNZM2410 mouse modelNZM2410 strainComponent phenotypesChromosome 17Congenic miceGenesMarker-assisted selection protocolSusceptibility allelesPolygenic modelComplex pathogenic mechanismsSelection protocolPathogenic mechanisms