Karin Reinisch, PhD
David W. Wallace Professor of Cell Biology and of Molecular Biophysics and BiochemistryCards
About
Research
Publications
2026
Mechanism of lipid transfer by bridge-like protein VPS13A and the scramblase XK
Hu B, Álvarez D, Rocha-Roa C, Guyard V, Li D, Ahmed Y, Wang X, De Camilli P, Vanni S, Reinisch K. Mechanism of lipid transfer by bridge-like protein VPS13A and the scramblase XK. Cell 2026 PMID: 42285089, PMCID: PMC13267863, DOI: 10.1016/j.cell.2026.05.027.Peer-Reviewed Original Research
2025
Reconstitution approaches for understanding cellular lipid dynamics
Li D, Korfhage J, Reinisch K. Reconstitution approaches for understanding cellular lipid dynamics. Methods In Enzymology 2025, 727: 233-251. PMID: 41765593, DOI: 10.1016/bs.mie.2025.11.022.ChaptersATG2 is a triglyceride transfer protein
Korfhage J, Elhan H, Wan N, Lu Y, Kauffmann L, Pilli G, Fuller D, Rios A, Reinisch K, Maddipati K, Thiam A, Melia T. ATG2 is a triglyceride transfer protein. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2517469122. PMID: 41296734, PMCID: PMC12685032, DOI: 10.1073/pnas.2517469122.Peer-Reviewed Original ResearchKey challenges and recommendations for defining organelle membrane contact sites
Calì T, Bayer E, Eden E, Hajnóczky G, Kornmann B, Lackner L, Liou J, Reinisch K, Rhee H, Rizzuto R, Scorrano L, Brini M. Key challenges and recommendations for defining organelle membrane contact sites. Nature Reviews Molecular Cell Biology 2025, 26: 776-796. PMID: 40550870, DOI: 10.1038/s41580-025-00864-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsStructural clues about bridge-mediated lipid transfer
De Camilli P, Reinisch K. Structural clues about bridge-mediated lipid transfer. Nature Structural & Molecular Biology 2025, 32: 961-963. PMID: 40374928, DOI: 10.1038/s41594-025-01552-2.Peer-Reviewed Original ResearchVAC14 oligomerization is essential for the function of the FAB1/PIKfyve-VAC14-FIG4 complex
Zhang L, Uygun T, Hahn H, Liu Y, Rivero-Ríos P, Li D, Navratna V, Bristow E, Luo G, Kovarzin A, Bo Y, Gadde S, Côté M, Ko D, Mosalaganti S, Reinisch K, Weisman L. VAC14 oligomerization is essential for the function of the FAB1/PIKfyve-VAC14-FIG4 complex. Molecular Biology Of The Cell 2025, 36: ar78-ar78. PMID: 40305106, PMCID: PMC12260172, DOI: 10.1091/mbc.e24-11-0490.Peer-Reviewed Original ResearchCryoelectron MicroscopyFlavoproteinsHexosyltransferasesHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMutationPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesPhosphoric Monoester HydrolasesPhosphotransferases (Alcohol Group Acceptor)Protein BindingProtein MultimerizationSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsVesicular Transport ProteinsLipid Dynamics at Membrane Contact Sites
Reinisch K, De Camilli P, Melia T. Lipid Dynamics at Membrane Contact Sites. Annual Review Of Biochemistry 2025, 94: 479-502. PMID: 40067957, DOI: 10.1146/annurev-biochem-083024-122821.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2024
Lipid scrambling is a general feature of protein insertases
Li D, Rocha-Roa C, Schilling M, Reinisch K, Vanni S. Lipid scrambling is a general feature of protein insertases. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2319476121. PMID: 38621120, PMCID: PMC11047089, DOI: 10.1073/pnas.2319476121.Peer-Reviewed Original ResearchSpartin-mediated lipid transfer facilitates lipid droplet turnover
Wan N, Hong Z, Parson M, Korfhage J, Burke J, Melia T, Reinisch K. Spartin-mediated lipid transfer facilitates lipid droplet turnover. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2314093121. PMID: 38190532, PMCID: PMC10801920, DOI: 10.1073/pnas.2314093121.Peer-Reviewed Original Research
2016
Control of plasma membrane lipid homeostasis by the extended synaptotagmins
Saheki Y, Bian X, Schauder CM, Sawaki Y, Surma MA, Klose C, Pincet F, Reinisch KM, De Camilli P. Control of plasma membrane lipid homeostasis by the extended synaptotagmins. Nature Cell Biology 2016, 18: 504-515. PMID: 27065097, PMCID: PMC4848133, DOI: 10.1038/ncb3339.Peer-Reviewed Original Research
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- April 25, 2024
3 From Yale School of Medicine Elected to American Academy of Arts and Sciences
- February 26, 2024
CASE Announces Newly Elected Members
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