2025
3 Cerebrospinal Fluid
Al Bizri E, Benveniste H. 3 Cerebrospinal Fluid. 2025, 67-76. DOI: 10.1016/b978-0-323-93273-8.00003-1.Peer-Reviewed Original Research
2024
Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer’s disease
Koundal S, Chen X, Gursky Z, Lee H, Xu K, Liang F, Xie Z, Xu F, Lin H, Van Nostrand W, Gu X, Elkin R, Tannenbaum A, Benveniste H. Divergent brain solute clearance in rat models of cerebral amyloid angiopathy and Alzheimer’s disease. IScience 2024, 111463. DOI: 10.1016/j.isci.2024.111463.Peer-Reviewed Original ResearchIs CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies
van Veluw S, Benveniste H, Bakker E, Carare R, Greenberg S, Iliff J, Lorthois S, Van Nostrand W, Petzold G, Shih A, van Osch M. Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies. Cellular And Molecular Life Sciences 2024, 81: 239. PMID: 38801464, PMCID: PMC11130115, DOI: 10.1007/s00018-024-05277-1.Peer-Reviewed Original ResearchA translational approach towards understanding brain waste clearance in cerebral amyloid angiopathy
van Veluw S, Benveniste H, van Osch M, Bakker E, Carare R, Greenberg S, Iliff J, Lorthois S, Van Nostrand W, Petzold G, Shih A. A translational approach towards understanding brain waste clearance in cerebral amyloid angiopathy. European Heart Journal 2024, 45: 1500-1502. PMID: 38289319, DOI: 10.1093/eurheartj/ehae011.Peer-Reviewed Original ResearchUnbalanced regularized optimal mass transport with applications to fluid flows in the brain
Chen X, Benveniste H, Tannenbaum A. Unbalanced regularized optimal mass transport with applications to fluid flows in the brain. Scientific Reports 2024, 14: 1111. PMID: 38212659, PMCID: PMC10784574, DOI: 10.1038/s41598-023-50874-y.Peer-Reviewed Original ResearchConceptsFluid flowMass transportEntire transport processNumerical solution procedureKinetic energyTotal kinetic energyImage trackingSolution procedureOptimal mass transportTransport processesMass transport approachTransport problemsMass configurationConstraint equationsFlowTransport approachApplicationsBenamouFormulationTransportTrackingCerebral Proteomic Changes in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2 With Cortical Microhemorrhages and Cognitive Impairments
Schrader J, Majchrzak M, Xu F, Lee H, Agostinucci K, Davis J, Benveniste H, Van Nostrand W. Cerebral Proteomic Changes in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2 With Cortical Microhemorrhages and Cognitive Impairments. Neuroscience Insights 2024, 19: 26331055241288172. PMID: 39386146, PMCID: PMC11462563, DOI: 10.1177/26331055241288172.Peer-Reviewed Original ResearchCerebral amyloid angiopathyPathogenesis of cerebral amyloid angiopathyTGF-b1Rat modelTGF-b1 levelsType 2Few proteinsSmooth muscle cell lossTransforming growth factor beta 1Wild-type ratsProteomic changesB proteinProteomic analysisPeptidase ATransgenic rat modelPathway analysisMolecular insightsMagnetic resonance imagingCognitive impairmentAlzheimer's diseaseCell lossAmyloid depositsRatsAmyloid angiopathyCortical microhemorrhages
2023
Author Correction: Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries
Chen X, Liu X, Koundal S, Elkin R, Zhu X, Monte B, Xu F, Dai F, Pedram M, Lee H, Kipnis J, Tannenbaum A, Van Nostrand W, Benveniste H. Author Correction: Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries. Nature Aging 2023, 3: 1603-1603. PMID: 38001312, DOI: 10.1038/s43587-023-00544-5.Peer-Reviewed Original ResearchVisualizing Fluid Flows via Regularized Optimal Mass Transport with Applications to Neuroscience
Chen X, Tran A, Elkin R, Benveniste H, Tannenbaum A. Visualizing Fluid Flows via Regularized Optimal Mass Transport with Applications to Neuroscience. Journal Of Scientific Computing 2023, 97: 26. PMID: 38938875, PMCID: PMC11210720, DOI: 10.1007/s10915-023-02337-9.Peer-Reviewed Original ResearchMass transport problemFluid flowOptimal mass transport problemComputational fluid dynamicsTransport problemsFluid dynamicsMass transportPrevious numerical methodsDynamic formulationOptimal mass transportContinuity equationNumerical methodNumerical resultsDiffusion termPresent workComputational runtimeFlowEfficient implementationBrenierBenamouContinuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport
Ozturk B, Koundal S, Al Bizri E, Chen X, Gursky Z, Dai F, Lim A, Heerdt P, Kipnis J, Tannenbaum A, Lee H, Benveniste H. Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport. JCI Insight 2023, 8: e170270. PMID: 37159262, PMCID: PMC10371231, DOI: 10.1172/jci.insight.170270.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePositive airway pressureGlymphatic transportAirway pressureIntracranial pressureEnd-expiratory lung volumeCSF bulk flowCerebrospinal fluid flowArterial oxygenationUpper airwayLung volumeCPAP deviceRespiratory functionClearance functionTherapeutic benefitSkull baseAnesthetized rodentsCSF flowFluid homeostasisPhysiological testingLymphatic systemFunctional crosstalkClinical devicesAirwayRatsNeurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCO2, and pO2
DiNuzzo M, Dienel G, Behar K, Petroff O, Benveniste H, Hyder F, Giove F, Michaeli S, Mangia S, Herculano‐Houzel S, Rothman D. Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCO2, and pO2. Journal Of Neurochemistry 2023, 168: 632-662. PMID: 37150946, PMCID: PMC10628336, DOI: 10.1111/jnc.15839.Peer-Reviewed Original ResearchHigher cerebral blood flowCerebral blood flowOxygen extraction fractionNeurovascular couplingBlood flowLower oxygen extraction fractionNonoxidative glycolysisCerebral metabolic rateBrain pHCapillary densityNeurovascular diseasesNonoxidative metabolismTissue oxygenationHuman cortexBrain functionExtraction fractionBrain activationMitochondrial ATP productionPET measurementsCMROOxygen consumptionHomeostasisGlycogenolysisFMRI contrastActivationGlobal sonication of the human intracranial space via a jumbo planar transducer
Brinker S, Yoon K, Benveniste H. Global sonication of the human intracranial space via a jumbo planar transducer. Ultrasonics 2023, 134: 107062. PMID: 37343366, DOI: 10.1016/j.ultras.2023.107062.Peer-Reviewed Original ResearchConceptsPlanar transducerAcoustic intensityUltrasound beamAcoustic wave reflectionFocused ultrasound beamHuman skull specimensTherapeutic ultrasound applicationsElectrical powerSpatial-peak pulse-average intensityField uniformityTransmission lossField characterizationWave behaviorUltrasound applicationWave reflectionPulse average intensityTreatment envelopeComputational simulationsUltrasound energyPulse parametersStimulation regionSimulationsBeamLens effectTransducer195 Aberrant Brain Biomechanics Initiates Ventricular Dilation in a Genetic Subtype of Congenital Hydrocephalus
Phan D, Dahl P, Koundal S, Pedram M, Deniz E, Benveniste H, Malvankar N, Kahle K. 195 Aberrant Brain Biomechanics Initiates Ventricular Dilation in a Genetic Subtype of Congenital Hydrocephalus. Neurosurgery 2023, 69: 32-32. DOI: 10.1227/neu.0000000000002375_195.Peer-Reviewed Original ResearchVentricular dilationCongenital hydrocephalusCongenital brain malformationsHuman congenital hydrocephalusCerebrospinal fluid circulationNeural stem cell proliferationCortical hypoplasiaAqueductal obstructionBrain parenchymaBrain malformationsMouse modelHydrocephalus patientsNeurogenesis resultsVentricular expansionNeural stem cell fateCSF circulationIntracranial physiologyCSF flowGenetic subtypesPrimary physiological factorCSF dynamicsCell proliferationCSFSame point mutationHydrocephalusActivation of brain arousal networks coincident with eye blinks during resting state.
Demiral Ş, Kure Liu C, Benveniste H, Tomasi D, Volkow N. Activation of brain arousal networks coincident with eye blinks during resting state. Cerebral Cortex 2023, 33: 6792-6802. PMID: 36653022, PMCID: PMC10233245, DOI: 10.1093/cercor/bhad001.Peer-Reviewed Original Research
2022
CSF-to-dura gateways
Thomas J, Benveniste H. CSF-to-dura gateways. Journal Of Experimental Medicine 2022, 220: e20221719. PMID: 36472584, PMCID: PMC9729850, DOI: 10.1084/jem.20221719.Peer-Reviewed Original ResearchGlymphatic System
Benveniste H, Nedergaard M. Glymphatic System. 2022, 2271-2288. DOI: 10.1007/978-3-030-88832-9_138.Peer-Reviewed Original ResearchPublisher Correction: Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries
Chen X, Liu X, Koundal S, Elkin R, Zhu X, Monte B, Xu F, Dai F, Pedram M, Lee H, Kipnis J, Tannenbaum A, Van Nostrand W, Benveniste H. Publisher Correction: Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries. Nature Aging 2022, 2: 454-454. PMID: 37118076, DOI: 10.1038/s43587-022-00223-x.Peer-Reviewed Original Research
2021
Transgenic rat models for cerebral amyloid angiopathy type‐1 and ‐2 and related vascular cognitive impairment and dementia (VCID)
Van Nostrand W, Xu F, Lee H, Robinson J, Benveniste H. Transgenic rat models for cerebral amyloid angiopathy type‐1 and ‐2 and related vascular cognitive impairment and dementia (VCID). Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.051368.Peer-Reviewed Original ResearchCerebral amyloid angiopathyType 2 ratsWhite matter lossType 1 ratsMonths of ageCAA type 1Vascular cognitive impairmentTransgenic rat modelMagnetic resonance imagingType 1CAA pathologyCerebral microbleedsPathological featuresRat modelTypes of CAAType 2Cognitive impairmentCerebral small vessel diseaseHistological analysisNovel transgenic rat modelSmall vessel diseaseWhite matter changesReliable preclinical modelsCognitive changesParticular pathological features
2016
Glymphatic System
Benveniste H, Nedergaard M. Glymphatic System. 2016, 1945-1962. DOI: 10.1007/978-1-4939-3474-4_138.Peer-Reviewed Original ResearchP.1.i.012 Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression
Jørgensen A, Magnusson P, Hanson L, Kirkegaard T, Benveniste H, Lee H, Svarer C, Mikkelsen J, Fink-Jensen A, Knudsen G, Paulson O, Bolwig T, Jørgensen M. P.1.i.012 Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression. European Neuropsychopharmacology 2016, 26: s304-s305. DOI: 10.1016/s0924-977x(16)31208-1.Peer-Reviewed Original ResearchThe glymphatic system
Benveniste H, Nedergaard M. The glymphatic system. Neurology Psychiatry And Brain Research 2016, 22: 2. DOI: 10.1016/j.npbr.2015.12.006.Peer-Reviewed Original Research