Calcitonin gene-related peptide mediates hypotension and tachycardia in endotoxic rats
Huttemeier P, Ritter E, Benveniste H. Calcitonin gene-related peptide mediates hypotension and tachycardia in endotoxic rats. American Journal Of Physiology 1993, 265: h767-h769. PMID: 8368378, DOI: 10.1152/ajpheart.1993.265.2.h767.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood PressureCalcitonin Gene-Related PeptideEndotoxinsEscherichia coliFemaleHeart RateHypotensionPeptide FragmentsRatsRats, Inbred F344TachycardiaConceptsAcute circulatory changesCirculatory changesSurvival rateCalcitonin gene-related peptide concentrationsCalcitonin gene-related peptideMean blood pressureOverall survival rateGene-related peptideRegional blood flowEscherichia coli endotoxinClinical sepsisSevere hypotensionBlood pressureEndotoxic ratsCardiac functionCGRP antagonismColi endotoxinBlood flowUntreated animalsHypotensionTachycardiaSepsisRatsCGRPHCGRP