Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression
Jorgensen A, Magnusson P, Hanson L, Kirkegaard T, Benveniste H, Lee H, Svarer C, Mikkelsen J, Fink-Jensen A, Knudsen G, Paulson O, Bolwig T, Jorgensen M. Regional brain volumes, diffusivity, and metabolite changes after electroconvulsive therapy for severe depression. Acta Psychiatrica Scandinavica 2015, 133: 154-164. PMID: 26138003, DOI: 10.1111/acps.12462.Peer-Reviewed Original ResearchElectroconvulsive therapyDiffusion tensor imagingDorsolateral prefrontal cortexAntidepressant effectsSevere depressionMetabolite changesRegional brain volumesBrain metabolite concentrationsProton MR spectroscopyT MR scanAntidepressant actionClinical responseHippocampal plasticityHippocampal volumeAmygdala volumeMagnetic resonanceBrain volumeOrbitofrontal cortexPrefrontal cortexBrain structuresTensor imagingMR spectroscopyMR scansLack of correlationMetabolite concentrations