1996
A Newin VivoMethod for Quantitative Analysis of Stroke Lesions Using Diffusion-Weighted Magnetic Resonance Microscopy
Hall W, Benveniste H, Hedlund L, Johnson G. A Newin VivoMethod for Quantitative Analysis of Stroke Lesions Using Diffusion-Weighted Magnetic Resonance Microscopy. NeuroImage 1996, 3: 158-166. PMID: 9345486, DOI: 10.1006/nimg.1996.0017.Peer-Reviewed Original Research
1993
Microdialysis measurements of PGD2, TXB2 and 6-keto-PGF1α in rat CA1 hippocampus during transient cerebral ischemia
Huttemeier P, Kamiyama Y, Su M, Watkins W, Benveniste H. Microdialysis measurements of PGD2, TXB2 and 6-keto-PGF1α in rat CA1 hippocampus during transient cerebral ischemia. Prostaglandins 1993, 45: 177-187. PMID: 8430228, DOI: 10.1016/0090-6980(93)90033-4.Peer-Reviewed Original ResearchConceptsCerebral ischemiaPGF1 alphaMicrodialysis probeRat CA1 hippocampusGlobal cerebral ischemiaTransient cerebral ischemiaRole of PGD2Arachidonic acid metabolismAverage peak concentrationDistinct brain regionsIschemic brainEicosanoid concentrationsCA1 hippocampusEicosanoid releaseAA metabolitesPG metabolitesMicrodialysis measurementsBaseline levelsBrain regionsIschemiaPGD2TXB2Implanted microdialysis probesPeak concentrationAcid metabolismIschemia as an Excitotoxic Lesion: Protection Against Hippocampal Nerve Cell Loss by Denervation
Diemer N, Johansen F, Benveniste H, Bruhn T, Berg M, Valente E, Jørgensen M. Ischemia as an Excitotoxic Lesion: Protection Against Hippocampal Nerve Cell Loss by Denervation. Acta Neurochirurgica Supplement 1993, 57: 94-101. PMID: 8380675, DOI: 10.1007/978-3-7091-9266-5_14.Peer-Reviewed Original ResearchConceptsPyramidal neuronsIschemic neuron damageVulnerable nerve cellsTransient cerebral ischemiaGABA-ergic interneuronsNerve cell lossMin of ischemiaHippocampal pyramidal neuronsRelease of glutamateExtracellular glutamate releaseKainate/Neuroexcitatory mechanismsNeuron damagePostischemic periodCerebral ischemiaHilus cellsPostischemic hypoperfusionCalcium blockersGlutamate releaseIntact innervationIschemic animalsDenervated ratsDentate hilusReceptor autoradiographyCA1 neurons
1992
EFFECTS OF DANTROLENE ON HISTOLOGICAL OUTCOME IN RAT CAL HIPPOCAMPUS AFTER GLOBAL TRANSIENT CEREBRAL ISCHEMIA
KAMIYAMA Y, SHIRAISHI M, BENVENISTE H, WATKINS W, HüTTEMEIER P. EFFECTS OF DANTROLENE ON HISTOLOGICAL OUTCOME IN RAT CAL HIPPOCAMPUS AFTER GLOBAL TRANSIENT CEREBRAL ISCHEMIA. Anesthesiology 1992, 77: a781. DOI: 10.1097/00000542-199209001-00781.Peer-Reviewed Original ResearchMechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy.
Benveniste H, Hedlund L, Johnson G. Mechanism of detection of acute cerebral ischemia in rats by diffusion-weighted magnetic resonance microscopy. Stroke 1992, 23: 746-754. PMID: 1374575, DOI: 10.1161/01.str.23.5.746.Peer-Reviewed Original ResearchConceptsAcute cerebral ischemiaCerebral ischemiaApparent diffusion coefficientOuabain exposureDiffusion-weighted magnetic resonance microscopyApparent diffusion coefficient reductionRight middle cerebral arteryIpsilateral common carotid arteryN-methyl-D-aspartate exposureFocal cerebral ischemiaMiddle cerebral arteryCommon carotid arteryApparent diffusion coefficient (ADC) valuesRat brain tissueTissue apparent diffusion coefficientCerebral arteryMicrodialysis membraneGlutamate exposureCorpus striatumOlfactory cortexCarotid arterySprague-DawleyBrain tissueIschemiaArtery
1991
Quantitative proton magnetic resonance imaging in focal cerebral ischemia in rat brain.
Benveniste H, Cofer G, Piantadosi C, Davis J, Johnson G. Quantitative proton magnetic resonance imaging in focal cerebral ischemia in rat brain. Stroke 1991, 22: 259-268. PMID: 2003291, DOI: 10.1161/01.str.22.2.259.Peer-Reviewed Original ResearchConceptsSelective neuronal injuryFocal cerebral ischemiaArea of injuryCerebral ischemiaNeuronal injuryTotal slice areaIschemic penumbraWistar ratsRat brainCresyl violet-stained brain sectionsMR imagingUpper cortical layersMale Wistar ratsPermanent unilateral occlusionCommon carotid arteryHistological sectionsArea of infarctionMR imagesNormal brain tissueMagnetic resonance imagingCerebral cortexUnilateral occlusionHistological damageHalothane anesthesiaCarotid arteryThe excitotoxin hypothesis in relation to cerebral ischemia.
Benveniste H. The excitotoxin hypothesis in relation to cerebral ischemia. Cerebrovascular And Brain Metabolism Reviews 1991, 3: 213-45. PMID: 1931486.Peer-Reviewed Original ResearchConceptsExcitatory amino acidsSelective neuronal deathExcitotoxin hypothesisNeuronal deathExtracellular glutamate concentration increasesSelective vulnerable brain regionsBrain regionsN-methyl-D-aspartate receptorsGlutamate accumulationBrain cell injuryVulnerable brain regionsTransient global ischemiaHigh-performance liquid chromatographyDistinct brain regionsNeuronal injuryBrain extracellular spaceCerebral ischemiaTransient ischemiaAntagonist APVExcitatory neurotransmitterGlobal ischemiaExtracellular glutamateNMDA antagonistsCertain neuronsMicrodialysis technique
1990
A715 Microdialysis measurements of arachidonic acid metabolites in rat CA1 hippocampus during transient cerebral ischemia
Benveniste H, Huttemeier P, Brothers M, Watkins W. A715 Microdialysis measurements of arachidonic acid metabolites in rat CA1 hippocampus during transient cerebral ischemia. Anesthesiology 1990, 73: na. DOI: 10.1097/00000542-199009001-00713.Peer-Reviewed Original Research
1988
Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemia
Benveniste H, Jørgensen M, Diemer N, Hansen A. Calcium accumulation by glutamate receptor activation is involved in hippocampal cell damage after ischemia. Acta Neurologica Scandinavica 1988, 78: 529-536. PMID: 2906199, DOI: 10.1111/j.1600-0404.1988.tb03697.x.Peer-Reviewed Original ResearchConceptsGlutamate N-methyl-D-aspartate receptorN-methyl-D-aspartate receptorsCell damageNerve cell destructionComplete cerebral ischemiaBrain cell damageMin of ischemiaOnset of ischemiaHippocampal cell damageGlutamate receptor activationCA 1 regionRole of intracellularCerebral ischemiaIschemic periodBilateral destructionDenervated hippocampusAfferent inputSynaptic transmissionCalcium influxIschemiaCompetitive antagonistReceptor activationHistological studyCell destructionCalcium accumulation
1985
Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro
Drejer J, Benveniste H, Diemer N, Schousboe A. Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In Vitro. Journal Of Neurochemistry 1985, 45: 145-151. PMID: 2860206, DOI: 10.1111/j.1471-4159.1985.tb05486.x.Peer-Reviewed Original ResearchConceptsPotassium-induced releaseGlutamatergic neuronsAspartate uptakeConditions of hypoglycemiaCultured glutamatergic neuronsTransient cerebral ischemiaHigh potassiumExtracellular glutamate contentCerebral ischemiaGlutamate releaseTransmitter poolExtracellular glutamateMicrodialysis techniqueIschemiaBrain tissuePotassium stimulationPerfusion mediumHypoglycemiaGlutamate contentNeuronsInduced increasesCellular originVivo experimentsAstrocytesPrevious reports
1984
Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis
Benveniste H, Drejer J, Schousboe A, Diemer N. Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral Microdialysis. Journal Of Neurochemistry 1984, 43: 1369-1374. PMID: 6149259, DOI: 10.1111/j.1471-4159.1984.tb05396.x.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidCerebral ischemiaIschemic periodTransient complete cerebral ischemiaTransient cerebral ischemiaComplete cerebral ischemiaExtracellular contentAmino acid glutamateDiameter dialysisIntracerebral microdialysisConcentrations of alanineExtracellular glutamateRat hippocampusCertain neuronsTaurine concentrationsIschemiaExtracellular concentrationHippocampusExtracellular fluidRinger's solutionGlutamateSame periodAspartateCausal factorsPeriod