2023
Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCO2, and pO2
DiNuzzo M, Dienel G, Behar K, Petroff O, Benveniste H, Hyder F, Giove F, Michaeli S, Mangia S, Herculano‐Houzel S, Rothman D. Neurovascular coupling is optimized to compensate for the increase in proton production from nonoxidative glycolysis and glycogenolysis during brain activation and maintain homeostasis of pH, pCO2, and pO2. Journal Of Neurochemistry 2023, 168: 632-662. PMID: 37150946, PMCID: PMC10628336, DOI: 10.1111/jnc.15839.Peer-Reviewed Original ResearchHigher cerebral blood flowCerebral blood flowOxygen extraction fractionNeurovascular couplingBlood flowLower oxygen extraction fractionNonoxidative glycolysisCerebral metabolic rateBrain pHCapillary densityNeurovascular diseasesNonoxidative metabolismTissue oxygenationHuman cortexBrain functionExtraction fractionBrain activationMitochondrial ATP productionPET measurementsCMROOxygen consumptionHomeostasisGlycogenolysisFMRI contrastActivation
2008
Detection of Ca2+- Dependent Neuronal Activity Simultaneously With Dynamic Changes in Cerebral Blood Flow, Blood Volume and Oxygenation in Somatosensory Cortex of the Live Rat Brain
Du C, Luo Z, Yu M, Benveniste H. Detection of Ca2+- Dependent Neuronal Activity Simultaneously With Dynamic Changes in Cerebral Blood Flow, Blood Volume and Oxygenation in Somatosensory Cortex of the Live Rat Brain. 2008, btue3. DOI: 10.1364/biomed.2008.btue3.Peer-Reviewed Original Research
2007
Laser Doppler Speckle Contrast Imaging of Cerebral Blood Flow during Functional Activation in Rat Somatosensory Cortex
Luo Z, Benveniste H, Yu M, Pan Y, Du C. Laser Doppler Speckle Contrast Imaging of Cerebral Blood Flow during Functional Activation in Rat Somatosensory Cortex. 2007, 69-70. DOI: 10.1109/nebc.2007.4413283.Peer-Reviewed Original ResearchLocal cerebral blood flowCerebral blood flowBlood flowSomatosensory cortexLaser Doppler effectActivation-flow couplingLaser Doppler flowmetrySpeckle contrast imagingRat somatosensory cortexContrast imagingVivo animal studiesSpeckle contrastFunctional hyperemiaDoppler flowmetryAnimal studiesDoppler effectElectrical stimulationSpeckle changesFunctional activationBrain surfaceSpatial resolutionCortexActivity couplingCouplingTraditional point measurementsCocaine-Induced Cerebral Hemodynamic and Neuronal Function Changes in Vivo Measured by Laser Doppler Flowmetry
Tully M, Luo Z, Benveniste H, Yu M, Du C. Cocaine-Induced Cerebral Hemodynamic and Neuronal Function Changes in Vivo Measured by Laser Doppler Flowmetry. 2007, 156-158. DOI: 10.1109/nebc.2007.4413326.Peer-Reviewed Original Research
1995
Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion.
Zhang J, Benveniste H, Klitzman B, Piantadosi C. Nitric oxide synthase inhibition and extracellular glutamate concentration after cerebral ischemia/reperfusion. Stroke 1995, 26: 298-304. PMID: 7530389, DOI: 10.1161/01.str.26.2.298.Peer-Reviewed Original ResearchConceptsIschemia/reperfusionBlood-brain barrierCerebral blood flowBrain ischemia/reperfusionExcitatory amino acidsExtracellular glutamate concentrationL-NAMEBlood flowGlutamate concentrationSynthase inhibitionL-arginineExcitatory amino acid toxicityL-NAME-treated ratsPostischemic cerebral blood flowNitric oxide synthase inhibitionCerebral ischemia/reperfusionBlood-brain barrier functionL-arginine methyl esterCerebral blood flow responseBlood-brain barrier permeabilityGlobal brain ischemia/reperfusionElevated glutamate concentrationsImmediate postischemic periodInterstitial glutamate concentrationL-NAME administration
1991
MR imaging of microcirculation in rat brain: Correlation with carbon dioxide‐induced changes in blood flow
Maki J, Benveniste H, Macfall J, Piantadosi C, Johnson G. MR imaging of microcirculation in rat brain: Correlation with carbon dioxide‐induced changes in blood flow. Journal Of Magnetic Resonance Imaging 1991, 1: 673-681. PMID: 1823172, DOI: 10.1002/jmri.1880010609.Peer-Reviewed Original ResearchConceptsCerebral blood flowRat cerebral blood flowBlood flowArterial carbon dioxide pressureLaser Doppler flowmetry studyMR imaging studiesMagnetic resonance imaging techniquesRat brainLDF valuesCarbon dioxide pressureImaging studiesMR imagingTissue microcirculationImaging valuesPaCO2MicrocirculationQualitative pictureMotion sensitivityPresent studyCarbon dioxide-induced changeImaging techniquesFC techniqueRat motionsGradient coilsImaging
1987
Regional Cerebral Glucose Phosphorylation and Blood Flow After Insertion of a Microdialysis Fiber Through the Dorsal Hippocampus in the Rat
Benveniste H, Drejer J, Schousboe A, Diemer N. Regional Cerebral Glucose Phosphorylation and Blood Flow After Insertion of a Microdialysis Fiber Through the Dorsal Hippocampus in the Rat. Journal Of Neurochemistry 1987, 49: 729-734. PMID: 3612121, DOI: 10.1111/j.1471-4159.1987.tb00954.x.Peer-Reviewed Original ResearchConceptsLocal cerebral blood flowBlood flowDorsal hippocampusGlucose metabolismMicrodialysis fibersLocal cerebral glucose metabolismCerebral glucose metabolismCerebral blood flowRat dorsal hippocampusGlucose phosphorylationNear normalizationFocal disturbanceRecovery periodPronounced disturbancesHippocampusRatsImplantationMetabolismPhosphorylationRecovery timeGliosisSlight reductionLCMRglcLCMRglu