Elizabeth Eynon, PhD
Research Scientist in ImmunobiologyDownloadHi-Res Photo
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Chair, IACUC
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About
Titles
Research Scientist in Immunobiology
Chair, IACUCEducation & Training
- Postdoctoral Fellow
- Netherlands Cancer Institute (1995)
- PhD
- University of Massachusetts (1991)
Research
Overview
My current reseach involves characterization of mice that support human cells and tissues. These mice have been generated in the Flavell lab to have transgenic expression of human genes used to support correct expression and differentiation mostly of cells of the immune system when transplanted into these model mice.
Medical Subject Headings (MeSH)
Autoimmune Diseases
Publications
2011
Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/− mice improves engraftment of human hematopoietic cells in humanized mice
Strowig T, Rongvaux A, Rathinam C, Takizawa H, Borsotti C, Philbrick W, Eynon EE, Manz MG, Flavell RA. Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/− mice improves engraftment of human hematopoietic cells in humanized mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 13218-13223. PMID: 21788509, PMCID: PMC3156175, DOI: 10.1073/pnas.1109769108.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsAntigens, DifferentiationBone Marrow CellsCell LineageDNA-Binding ProteinsEpitopesHematopoietic Stem Cell TransplantationHematopoietic Stem CellsHumansImmunity, HumoralInterleukin Receptor Common gamma SubunitMiceMice, Inbred BALB CMice, KnockoutMice, TransgenicReceptors, ImmunologicTransgenesConceptsSignal regulatory protein alphaBALB/c backgroundRegulatory protein alphaNSG miceImmune systemC backgroundHuman hematopoietic cellsNOD/SCID/Mouse strainsProtein alphaHuman cell engraftmentBALB/cUnique mouse strainHost immune functionHematopoietic cellsHuman immune systemHumanized miceSCID/Human hematopoietic stem cellsImmune responseHuman engraftmentSimilar miceImmune functionNewborn miceCell engraftmentEfficient differentiation and function of human macrophages in humanized CSF-1 mice
Rathinam C, Poueymirou WT, Rojas J, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rongvaux A, Eynon EE, Manz MG, Flavell RA. Efficient differentiation and function of human macrophages in humanized CSF-1 mice. Blood 2011, 118: 3119-3128. PMID: 21791433, DOI: 10.1182/blood-2010-12-326926.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHuman monocytes/macrophagesMonocytes/macrophagesMice showHumanized mouse modelMyeloid cell biologyBALB/cHuman fetal liverHuman myeloid cellsHumanized micePeripheral bloodPeritoneal cavityMouse modelNewborn miceBone marrowMyeloid cellsHuman cytokinesHuman hematopoietic systemHuman macrophagesMiceValuable experimental modelExperimental modelFetal liverProgenitor cellsHuman IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung
Willinger T, Rongvaux A, Takizawa H, Yancopoulos GD, Valenzuela DM, Murphy AJ, Auerbach W, Eynon EE, Stevens S, Manz MG, Flavell RA. Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 2390-2395. PMID: 21262803, PMCID: PMC3038773, DOI: 10.1073/pnas.1019682108.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsCord Blood Stem Cell TransplantationGene Knock-In TechniquesGranulocyte-Macrophage Colony-Stimulating FactorHumansImmunity, InnateImmunity, MucosalInfluenza A Virus, H1N1 SubtypeInterleukin-3LungMacrophages, AlveolarMiceMice, TransgenicModels, ImmunologicalOrthomyxoviridae InfectionsTransplantation ChimeraTransplantation, HeterologousConceptsHuman immune responseImmune responseHuman alveolar macrophagesKI miceAlveolar macrophagesFunctional human immune systemHuman mucosal immune responsesGM-CSFHuman innate immune responseMucosal immune responsesPulmonary alveolar proteinosisHuman immune cellsInnate immune responseUnique mouse modelKnock-In MiceHuman immune systemAlveolar macrophage developmentHuman myeloid cellsHuman infectious diseasesCell reconstitutionHumanized miceAlveolar proteinosisImmune cellsMouse GM-CSFVaccine testingHuman thrombopoietin knockin mice efficiently support human hematopoiesis in vivo
Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Eynon EE, Stevens S, Manz MG, Flavell RA. Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 2378-2383. PMID: 21262827, PMCID: PMC3038726, DOI: 10.1073/pnas.1019524108.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2010
The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell–mediated peripheral T cell unresponsiveness
Hawiger D, Wan YY, Eynon EE, Flavell RA. The transcription cofactor Hopx is required for regulatory T cell function in dendritic cell–mediated peripheral T cell unresponsiveness. Nature Immunology 2010, 11: 962-968. PMID: 20802482, PMCID: PMC2943559, DOI: 10.1038/ni.1929.Peer-Reviewed Original ResearchCitationsMeSH Keywords and Concepts
Academic Achievements and Community Involvement
activity Vice Chair
CommitteesIACUC Committee
Links & Media
News
- February 01, 2010
Autoimmunity: research on many fronts
- February 10, 2008
New Yale Research Center Focuses on Rheumatic and Immunologic Diseases
- September 15, 2005
A mouse offers a new way to test vaccines
- September 01, 2005
Mouse breakthrough will speed vaccines