2010
A translational bridge between mouse and human models of learned safety
Pollak DD, Rogan MT, Egner T, Perez DL, Yanagihara TK, Hirsch J. A translational bridge between mouse and human models of learned safety. Annals Of Medicine 2010, 42: 127-134. PMID: 20121549, DOI: 10.3109/07853890903583666.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexNeural circuitryPrefrontal cortexAnimal experimentsTranslational bridgeFunctional magnetic resonanceParallel groupSafety signalsPupillary constrictionNoxious stimuliUnderlying neural circuitryHuman studiesExperimental animalsHuman modelNeural connectionsAnimal protocolsMiceCaudate responseNeutral stimuliNeural responsesNeural substratesDiffusion tensorAmygdalaCortexMolecular mechanisms
2006
Resolving Emotional Conflict: A Role for the Rostral Anterior Cingulate Cortex in Modulating Activity in the Amygdala
Etkin A, Egner T, Peraza DM, Kandel ER, Hirsch J. Resolving Emotional Conflict: A Role for the Rostral Anterior Cingulate Cortex in Modulating Activity in the Amygdala. Neuron 2006, 51: 871-882. PMID: 16982430, DOI: 10.1016/j.neuron.2006.07.029.Peer-Reviewed Original ResearchConceptsRostral anterior cingulate cortexAnterior cingulate cortexFunctional magnetic resonance imagingCingulate cortexEmotional conflictAmygdalar activityRostral cingulate cortexMagnetic resonance imagingDorsolateral prefrontal cortexRostral cingulateResonance imagingPrefrontal cortexModulating activityCortexConflict taskSalient stimuliNeural activityNeural mechanismsMental functioningActivationConflictActivityAmygdalaFacial Emotion Recognition after Curative Nondominant Temporal Lobectomy in Patients with Mesial Temporal Sclerosis
McClelland S, Garcia RE, Peraza DM, Shih TT, Hirsch LJ, Hirsch J, Goodman RR. Facial Emotion Recognition after Curative Nondominant Temporal Lobectomy in Patients with Mesial Temporal Sclerosis. Epilepsia 2006, 47: 1337-1342. PMID: 16922878, DOI: 10.1111/j.1528-1167.2006.00557.x.Peer-Reviewed Original ResearchConceptsMesial temporal sclerosisAnteromedial temporal lobectomyTemporal lobe epilepsyTLE onsetTemporal sclerosisTemporal lobectomyRight amygdalaEarly-onset patientsLate-onset patientsEarly-onset groupLate-onset groupAmygdalar damageAge 6 yearsFER impairmentPostsurgical populationLobe epilepsyLeft-hemisphere language dominancePreoperative MRIPatientsFrightened expressionImpaired facial emotion recognitionLobectomySclerosisAmygdalaOnset
2004
Individual Differences in Trait Anxiety Predict the Response of the Basolateral Amygdala to Unconsciously Processed Fearful Faces
Etkin A, Klemenhagen KC, Dudman JT, Rogan MT, Hen R, Kandel ER, Hirsch J. Individual Differences in Trait Anxiety Predict the Response of the Basolateral Amygdala to Unconsciously Processed Fearful Faces. Neuron 2004, 44: 1043-1055. PMID: 15603746, DOI: 10.1016/j.neuron.2004.12.006.Peer-Reviewed Original ResearchConceptsTrait anxietyFearful facesIndividual differencesDorsal amygdalaThreat-related stimuliBasolateral amygdalaSubjects' reaction timesReaction timeConscious stimuliUnconscious stimuliUnconscious processingConscious processingThreat sensitivityUnconscious perceptionUnconscious processesNeural responsesBasolateral subregionsNeural systemsAnxietyAmygdalaStimuliBiological basisProcessingFaceFMRI