1998
Deficits in Smooth-Pursuit Eye Movements After Muscimol Inactivation Within the Primate's Frontal Eye Field
Shi D, Friedman H, Bruce C. Deficits in Smooth-Pursuit Eye Movements After Muscimol Inactivation Within the Primate's Frontal Eye Field. Journal Of Neurophysiology 1998, 80: 458-464. PMID: 9658064, DOI: 10.1152/jn.1998.80.1.458.Peer-Reviewed Original ResearchConceptsFrontal eye fieldSmooth eye movement regionPrimate frontal eye fieldMuscimol injectionsArcuate sulcusEye fieldGamma-aminobutyric acid agonistSP deficitsSmooth pursuit eye movementsMicroinjection of muscimolSmooth pursuit functionMuscimol inactivationEye movement directionInjected hemisphereReversible deficitsFEFsemPermanent deficitsNeuronal responsesPosterior bankAspiration lesionsLarge aspiration lesionsEye movementsMotion onsetNext dayMuscimol
1997
Suppression of Task-Related Saccades by Electrical Stimulation in the Primate's Frontal Eye Field
Burman D, Bruce C. Suppression of Task-Related Saccades by Electrical Stimulation in the Primate's Frontal Eye Field. Journal Of Neurophysiology 1997, 77: 2252-2267. PMID: 9163356, DOI: 10.1152/jn.1997.77.5.2252.Peer-Reviewed Original ResearchConceptsFrontal eye fieldPrimate frontal eye fieldSaccadic eye movementsElectrical stimulationEye fieldFEF sitesFoveal receptive fieldsSuppression of saccadesLow-intensity stimulationEye movementsCentral fixation targetMemory-guided saccadesAppropriate saccadeCortex anteriorFEF projectionsContraversive saccadesAnterior bankIntracortical microstimulationStimulation trialsPremotor cortexEvidence of suppressionReflexive saccadesMacaque monkeysSubcortical regionsFrontal lobe damage
1996
Neurons in the supplementary eye field of rhesus monkeys code visual targets and saccadic eye movements in an oculocentric coordinate system
Russo GS, Bruce CJ. Neurons in the supplementary eye field of rhesus monkeys code visual targets and saccadic eye movements in an oculocentric coordinate system. Journal Of Neurophysiology 1996, 76: 825-848. PMID: 8871203, DOI: 10.1152/jn.1996.76.2.825.Peer-Reviewed Original ResearchConceptsSupplementary eye fieldPresaccadic activitySaccadic eye movementsSEF neuronsOculocentric coordinate systemEye fieldEccentric orbital positionEye positionEye movementsInitial eye positionBeginning of saccadesMemory saccade taskFixation pointCentral fixation pointOculocentric coordinatesVisual cue presentationMacaque monkeysOculomotor rangeRhesus monkeysCraniocentric coordinatesNeuronsSaccade directionVisual targetsStimulus directionSaccades
1994
Neural responses related to smooth-pursuit eye movements and their correspondence with electrically elicited smooth eye movements in the primate frontal eye field
Gottlieb J, MacAvoy M, Bruce C. Neural responses related to smooth-pursuit eye movements and their correspondence with electrically elicited smooth eye movements in the primate frontal eye field. Journal Of Neurophysiology 1994, 72: 1634-1653. PMID: 7823092, DOI: 10.1152/jn.1994.72.4.1634.Peer-Reviewed Original ResearchConceptsSmooth eye movementsFrontal eye fieldPursuit neuronsEye movementsEye fieldPosterior bankPursuit directionPrimate frontal eye fieldMonkey frontal eye fieldSmooth pursuit eye movementsDirectional tuningBroad directional tuningSaccadic eye movementsSmooth pursuit trackingPursuit cellsMost neuronsIntracortical microstimulationPursuit velocityFEF neuronsFEF regionSmooth pursuitRhesus monkeysRegion involvementNeuron responsesNeurons
1993
Topography of projections to the frontal lobe from the macaque frontal eye fields
Stanton G, Bruce C, Goldberg M. Topography of projections to the frontal lobe from the macaque frontal eye fields. The Journal Of Comparative Neurology 1993, 330: 286-301. PMID: 8491870, DOI: 10.1002/cne.903300209.Peer-Reviewed Original ResearchConceptsFrontal eye fieldArcuate sulcusFrontal lobePrincipal sulcusInjection siteEye fieldIpsilateral frontal lobeMacaque frontal eye fieldTopography of projectionsSaccadic eye movementsTracer injection siteFEF areaFEF projectionsAnterior wallPosterior wallSubcortical connectionsElectrical elicitationMedial partUpper limbMacaque monkeysCortical layersSmall saccadesDorsomedial convexitySulcusEye movementsDorsolateral prefrontal lesions and oculomotor delayed-response performance: evidence for mnemonic "scotomas"
Funahashi S, Bruce C, Goldman-Rakic P. Dorsolateral prefrontal lesions and oculomotor delayed-response performance: evidence for mnemonic "scotomas". Journal Of Neuroscience 1993, 13: 1479-1497. PMID: 8463830, PMCID: PMC6576716, DOI: 10.1523/jneurosci.13-04-01479.1993.Peer-Reviewed Original ResearchConceptsMemory-guided eye movementsPrefrontal lesionsPrefrontal cortexEye movementsDelay periodDelayed-response deficitsDorsolateral prefrontal lesionsDelayed-response performancePeripheral visual cuesDelayed-response paradigmFrontal eye field regionVisual field locationsSaccadic reaction timesUnilateral lesionsSpatial memory functionIpsilateral cuesMonkey prefrontal cortexODR taskOpposite hemifieldSpatial cuesVisual cuesSimple sensoryMemory mechanismsMemory deficitsVisual targetsSmooth eye movements elicited by microstimulation in the primate frontal eye field
Gottlieb J, Bruce C, MacAvoy M. Smooth eye movements elicited by microstimulation in the primate frontal eye field. Journal Of Neurophysiology 1993, 69: 786-799. PMID: 8385195, DOI: 10.1152/jn.1993.69.3.786.Peer-Reviewed Original ResearchConceptsSmooth eye movementsFrontal eye field regionFixation targetEye movementsStimulation intensityPursuit systemPrimate frontal eye fieldCortex. 5Frontal eye fieldPeak velocityTrains of stimulationAverage peak velocityDegrees/sStationary fixation targetIpsilateral movementsMs. 2Principal sulcusEye velocityRetinal slipAdult monkeysElectrical stimulationEye fieldPosterior bankElectrode penetrationsStimulation siteEffect of eye position within the orbit on electrically elicited saccadic eye movements: a comparison of the macaque monkey's frontal and supplementary eye fields
Russo G, Bruce C. Effect of eye position within the orbit on electrically elicited saccadic eye movements: a comparison of the macaque monkey's frontal and supplementary eye fields. Journal Of Neurophysiology 1993, 69: 800-818. PMID: 8385196, DOI: 10.1152/jn.1993.69.3.800.Peer-Reviewed Original Research
1991
Neuronal activity related to saccadic eye movements in the monkey's dorsolateral prefrontal cortex
Funahashi S, Bruce C, Goldman-Rakic P. Neuronal activity related to saccadic eye movements in the monkey's dorsolateral prefrontal cortex. Journal Of Neurophysiology 1991, 65: 1464-1483. PMID: 1875255, DOI: 10.1152/jn.1991.65.6.1464.Peer-Reviewed Original ResearchConceptsSaccadic eye movementsSaccade-related activityPostsaccadic activityPS neuronsVGS taskPresaccadic activityContralateral visual fieldODR taskDorsolateral prefrontal cortexPrefrontal cortexEye movementsIpsilateral fieldPrincipal sulcusMonkey dorsolateral prefrontal cortexVertical meridianVisual fieldReciprocal response patternSingle neuron activityExcitatory responsesInhibitory responsesNeuronal activitySaccade taskNeuronsSaccade directionCortexSmooth-Pursuit Eye Movement Representation in the Primate Frontal Eye Field
MacAvoy M, Gottlieb J, Bruce C. Smooth-Pursuit Eye Movement Representation in the Primate Frontal Eye Field. Cerebral Cortex 1991, 1: 95-102. PMID: 1822728, DOI: 10.1093/cercor/1.1.95.Peer-Reviewed Original ResearchConceptsSmooth pursuit eye movementsFrontal eye fieldPrimate frontal eye fieldEye movementsEye fieldIpsilateral smooth pursuitElicit eye movementsSaccadic eye movementsElicited saccadesSmooth pursuitSuperficial lesionsExperimental lesionsTracking deficitsLesionsVentral regionSubstantial deficitsVisual motionMovement representationsDeficitsMicrostimulationNeurons
1990
Primate frontal eye fields. III. Maintenance of a spatially accurate saccade signal
Goldberg M, Bruce C. Primate frontal eye fields. III. Maintenance of a spatially accurate saccade signal. Journal Of Neurophysiology 1990, 64: 489-508. PMID: 2213128, DOI: 10.1152/jn.1990.64.2.489.Peer-Reviewed Original ResearchConceptsFrontal eye fieldDouble-step taskSaccadic eye movementsEye fieldPostsaccadic activitySecond saccadeEye movementsFirst saccadeMonkey frontal eye fieldRetinal coordinatesDouble-step paradigmRetina. 2Receptive fieldsMovement fieldsVisuomovement cellsCell receptive fieldsPresaccadic activityMovement cellsFlashed targetsSaccade signalOculomotor tasksNeuronsSingle neuronsSaccadesRetinal stimulation
1987
The role of striate cortex in the guidance of eye movements in the monkey
Segraves M, Goldberg M, Deng S, Bruce C, Ungerleider L, Mishkin M. The role of striate cortex in the guidance of eye movements in the monkey. Journal Of Neuroscience 1987, 7: 3040-3058. PMID: 3668615, PMCID: PMC6569180, DOI: 10.1523/jneurosci.07-10-03040.1987.Peer-Reviewed Original ResearchConceptsInitiation of saccadesCentral fixation pointLatency of saccadesSaccadic eye movementsStriate cortexSmooth pursuitEye velocityEye movementsImpaired fieldSmooth pursuit eye velocityFixation pointStep-ramp stimuliPursuit eye velocityIntact visual systemCortical ablationOculomotor abnormalitiesStimulus velocityFoveal targetAccurate saccadesStationary stimuliCortexSaccadesMonkeysVisual hemifieldLong latency
1986
The effect of attentive fixation on eye movements evoked by electrical stimulation of the frontal eye fields
Goldberg M, Bushnell M, Bruce C. The effect of attentive fixation on eye movements evoked by electrical stimulation of the frontal eye fields. Experimental Brain Research 1986, 61: 579-584. PMID: 3956616, DOI: 10.1007/bf00237584.Peer-Reviewed Original ResearchConceptsFrontal eye fieldEye fieldElectrical stimulationActive fixationAttentive fixationEye movementsVisual fixation targetBehavioral statesCerebral cortexEye velocityElicited saccadesLarge saccadesState of fixationFixation targetRhesus monkeysStimulating electrodesOculomotor systemEye positionSaccade amplitudeSaccadesVisual targetsStimulationMonkeysFixationResponsible factorsThe role of the arcuate frontal eye fields in the generation of saccadic eye movements
Goldberg M, Bruce C. The role of the arcuate frontal eye fields in the generation of saccadic eye movements. Progress In Brain Research 1986, 64: 143-154. PMID: 3726143, DOI: 10.1016/s0079-6123(08)63409-3.Peer-Reviewed Original Research
1985
Primate frontal eye fields. II. Physiological and anatomical correlates of electrically evoked eye movements
Bruce C, Goldberg M, Bushnell M, Stanton G. Primate frontal eye fields. II. Physiological and anatomical correlates of electrically evoked eye movements. Journal Of Neurophysiology 1985, 54: 714-734. PMID: 4045546, DOI: 10.1152/jn.1985.54.3.714.Peer-Reviewed Original ResearchConceptsFrontal eye fieldEye fieldArcuate sulcusPresaccadic neuronsSaccade directionArea 8Frontal eye field neuronsEye movementsBrodmann area 8Cortical gray matterSaccadic eye movementsAwake macaque monkeysArea 8APresaccadic activityAnterior bankVentrolateral portionDorsomedial portionElicited saccadesElectrical stimulationLarge saccadesMacaque monkeysGray matterElectrode penetrationsAnatomical correlatesSmall saccades
1984
Physiology of the frontal eye fields
Bruce C, Goldberg M. Physiology of the frontal eye fields. Trends In Neurosciences 1984, 7: 436-441. DOI: 10.1016/s0166-2236(84)80149-6.Peer-Reviewed Original Research