Monika P. Jadi, PhD
Assistant Professor of Psychiatry and of NeuroscienceCards
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About
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Assistant Professor of Psychiatry and of Neuroscience
Biography
Monika Jadi obtained her Ph.D. in Neuroengineering at the University of Southern California and did her postdoctoral training at the Salk Institute for Biological Studies in the Computational Neurobiology Laboratory. At Yale, she is an Assistant Professor in the Departments of Psychiatry and Neuroscience.
Dr. Jadi’s research involves discovering computational principles that are critical for flexible information processing in the brain, using cross-disciplinary approaches from applied physics and computer science. Her doctoral research resulted in the first characterization of computational flexibility mediated by location-specificity of synaptic inhibition in active dendrites of neurons, a ubiquitous anatomical signature in cortical circuits. She has studied models of cortical networks during her postdoctoral work, and proposed a novel mechanism of cortical oscillations that is controlled by the direct and indirect stimulation of inhibitory neurons. Subsequently, she has explored mechanisms of flexible modulation of cortical dynamics that are mediated by different inhibitory neuronal classes in the cortex. Complementing her computational modelling work, she has used novel data analysis methods to explore the temporal dynamics of population coding in the visual cortex. The current focus of her lab is using computational modeling as well as data modeling tools such as machine learning to study computations, information flow, temporal dynamics of population codes and role of neuromodulation in canonical columnar circuits of the cortex. Dr. Jadi is a recipient of the NIH Pathway to Independence award during her postdoctoral and early faculty years.
Appointments
Psychiatry
Assistant ProfessorPrimaryNeuroscience
Assistant ProfessorSecondary
Other Departments & Organizations
- Center for Biomedical Data Science
- Division of Molecular Psychiatry
- Interdepartmental Neuroscience Program
- Neuroscience
- Neuroscience Track
- Psychiatry
- Swartz Program in Theoretical Neurobiology
- Wu Tsai Institute
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Education & Training
- Postdoctoral Research Associate
- Salk Institute for Biological Studies (2017)
- PhD
- University of Southern California, Biomedical Engineering (2010)
Research
Overview
Medical Research Interests
ORCID
0000-0003-1092-5026- View Lab Website
Jadi Lab
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Anirvan Nandy, PhD
Steve W. C. Chang, PhD
Cerebral Cortex
Dendrites
Interneurons
Schizophrenia
Computational Biology
Publications
2024
Brain state and cortical layer-specific mechanisms underlying perception at threshold
Morton M, Denagamage S, Blume I, Reynolds J, Jadi M, Nandy A. Brain state and cortical layer-specific mechanisms underlying perception at threshold. ELife 2024, 12: rp91722. PMID: 39556415, PMCID: PMC11573349, DOI: 10.7554/elife.91722.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsHIT trialsProcessing of sensory stimuliStable retinal imageBehavioral statesExcitatory neuronsNeural activitySpontaneous activityElevated synchronyPerceptual thresholdsCortical layersMeasures of stateElectrophysiological activitySensory stimuliRetinal imagesVisual area V4TrialsHeightened arousalTarget stimuliStimulus identityElevated arousalSuperficial layersFeed-forward pathwayStimulus changeCortical columnsIdentical stimuliBrain state and cortical layer-specific mechanisms underlying perception at threshold
Morton M, Denagamage S, Blume I, Reynolds J, Jadi M, Nandy A. Brain state and cortical layer-specific mechanisms underlying perception at threshold. ELife 2024, 12 DOI: 10.7554/elife.91722.4.Peer-Reviewed Original ResearchConceptsHIT trialsProcessing of sensory stimuliStable retinal imageBehavioral statesExcitatory neuronsNeural activitySpontaneous activityElevated synchronyPerceptual thresholdsCortical layersMeasures of stateElectrophysiological activitySensory stimuliRetinal imagesVisual area V4TrialsHeightened arousalTarget stimuliStimulus identityElevated arousalSuperficial layersFeed-forward pathwayStimulus changeCortical columnsIdentical stimuliDevelopment of a Marmoset Apparatus for Automated Pulling to study cooperative behaviors
Meisner O, Shi W, Fagan N, Greenwood J, Jadi M, Nandy A, Chang S. Development of a Marmoset Apparatus for Automated Pulling to study cooperative behaviors. ELife 2024, 13 DOI: 10.7554/elife.97088.3.Peer-Reviewed Original ResearchDevelopment of a Marmoset Apparatus for Automated Pulling to study cooperative behaviors
Meisner O, Shi W, Fagan N, Greenwood J, Jadi M, Nandy A, Chang S. Development of a Marmoset Apparatus for Automated Pulling to study cooperative behaviors. ELife 2024, 13: rp97088. PMID: 39466838, PMCID: PMC11517257, DOI: 10.7554/elife.97088.Peer-Reviewed Original ResearchCitationsAltmetricSpatial context non-uniformly modulates inter-laminar information flow in the primary visual cortex
Xu X, Morton M, Denagamage S, Hudson N, Nandy A, Jadi M. Spatial context non-uniformly modulates inter-laminar information flow in the primary visual cortex. Neuron 2024 PMID: 39442514, DOI: 10.1016/j.neuron.2024.09.021.Peer-Reviewed Original ResearchAltmetricConceptsPrimary visual cortexVisual cortexInformation flowCommunication subspaceDimensionality reduction approachSensory hierarchyOrganization of objectsOutput layerSpatial organization of objectsInformation propagationPerceptual degradationCortical connectivityEffective feedback signalActivity of neuronal ensemblesContextual signalsInfluence information flowSpatial configurationNeuronal ensemblesNon-uniformityConfigurationReduction approachPredictive Remapping in Neural Networks: A Model Based on Corollary Discharge Signals for Visual Continuity Across Saccades
Nandy A, Xu X, Jadi M. Predictive Remapping in Neural Networks: A Model Based on Corollary Discharge Signals for Visual Continuity Across Saccades. Journal Of Vision 2024, 24: 1401. DOI: 10.1167/jov.24.10.1401.Peer-Reviewed Original ResearchSpatial configuration of contextual stimuli influences inter-laminar interactions in macaque primary visual cortex
Xu X, Morton M, Hudson N, Nandy A, Jadi M. Spatial configuration of contextual stimuli influences inter-laminar interactions in macaque primary visual cortex. Journal Of Vision 2024, 24: 338. DOI: 10.1167/jov.24.10.338.Peer-Reviewed Original ResearchCorrigendum to “The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors” [Neurobiol. Learn. Mem. 203 (2023) 107793]
Shi W, Meisner O, Blackmore S, Jadi M, Nandy A, Chang S. Corrigendum to “The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors” [Neurobiol. Learn. Mem. 203 (2023) 107793]. Neurobiology Of Learning And Memory 2024, 214: 107973. PMID: 39174377, PMCID: PMC11426288, DOI: 10.1016/j.nlm.2024.107973.Peer-Reviewed Original ResearchBrain-state mediated modulation of inter-laminar dependencies in visual cortex
Das A, Sheffield A, Nandy A, Jadi M. Brain-state mediated modulation of inter-laminar dependencies in visual cortex. Nature Communications 2024, 15: 5105. PMID: 38877026, PMCID: PMC11178935, DOI: 10.1038/s41467-024-49144-w.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsBrain state fluctuationsUnique dependenceSpatial attentionBehavioral outcomesState fluctuationsDeployment of spatial attentionDeployment of attentionBehaviorally relevant objectsComputational goalCluttered environmentsVisual cortexObject recognitionExcitatory populationHierarchical computationVisual area V4Internal fluctuationsDependenceRelevant objectsModulation patternsTask demandsEnhance information transferCortical networksNeural activityInformation transferArea V4
2023
The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors
Shi W, Meisner O, Blackmore S, Jadi M, Nandy A, Chang S. The orbitofrontal cortex: A goal-directed cognitive map framework for social and non-social behaviors. Neurobiology Of Learning And Memory 2023, 203: 107793. PMID: 37353191, PMCID: PMC10527225, DOI: 10.1016/j.nlm.2023.107793.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsOrbitofrontal cortexOFC functionCognitive mapsOFC neuronsNon-social domainCore brain areasNon-social behaviorsReward-based behaviorsValues-based behaviorSocial behaviorSocial contextBrain areasBehavioral contextSocial functionComplex representationSingle subjectCortexBehaviorTremendous knowledgeIntegrated viewContextTask spaceMAP frameworkRepresentationWide array
Academic Achievements & Community Involvement
honor Pathway to Independence (K99/R00)
National AwardNational Eye InstituteDetails05/01/2015United States
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