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Leadership

  • Director MacBrain Resource Center, Department of Neuroscience; Research Scientist, Neuroscience

    Dr. Duque began his training in neuroanatomy and physiology in Dr. Laszlo Zaborszky's lab at Rutgers University where he studied basal forebrain local circuits and corticopetal connections.  Having acquired a deep interest in the organization and function of the cerebral cortex, he moved to Yale to continue his training with Dr. Patricia Goldman-Rakic and later with Dr. David McCormick. When his interest turned to how environmental factors affect general brain organization, cortical circuitry and ultimately behavior, he joined the laboratory of Dr. Pasko Rakic, one of the few places in the world where access to timed pregnant monkeys in conjunction with state-of-the-art technologies is available. Dr. Duque’s familiarity with the material and concern about alternatives to animal experimentation have fueled his interest in creating, maintaining and expanding the availability of MacBrainResource to the larger neuroscience community.

Senior Staff

Student Staff

Associated Faculty

  • Albert E. Kent Professor of Neuroscience and Professor of Psychology; Member, Kavli Institute of Neuroscience at Yale University

    Dr. Arnsten is an international expert on the molecular regulation of higher cortical circuits, and a member of the National Academy of Medicine. She received her B.A. in Neuroscience from Brown University in 1976 (where she created the Neuroscience major), and her Ph.D. in Neuroscience from UCSD in 1981. She did post-doctoral research with Dr. Susan Iversen at Cambridge University in the UK, and with Dr. Patricia Goldman-Rakic at Yale. Dr. Arnsten's research examines the neural basis of higher cognition. Her work has revealed that the newly evolved cortical circuits that underlie higher cognition are uniquely regulated at the molecular level, conferring vulnerability in mental illness and age-related cognitive disorders such as Alzheimer's Disease. Arnsten's research has led to new treatments for cognitive disorders in humans, including the successful translation of guanfacine (IntunivTM) for the treatment of ADHD and related prefrontal cortical disorders.
  • Assistant Professor; Clinical Veterinarian

    Jenn came to Yale in 2015 with 3 years of experience as a laboratory animal clinician, and she became board-certified in laboratory animal medicine that year. She has also spent 2 years as a small animal practitioner and has 1 year of experience in shelter medicine. She attended veterinary school at University of Illinois and completed her laboratory animal medicine residency at Emory University. Jenn practices clinical medicine, is heavily involved in the resident training program, and provides support for biomedical research. Her most recent collaborations have involved translational surgical models used to study peritoneal dialysis, cardiac tamponade, and short bowel syndrome.
  • Associate Professor of Psychology; Associate Professor, Neuroscience; Member, Kavli Institute for Neuroscience

    Steve Chang is an Associate Professor of Psychology and of Neuroscience at Yale University. He is also a member of the Wu Tsai Institute and the Kavli Institute for Neuroscience at Yale. He is also the co-Director of Undergraduate Studies for the Yale's Neuroscience Major. His research investigates the neural mechanisms of social cognition and social decision-making. He has been at the forefront of using live social interaction paradigms for studying the neural mechanisms underlying social decision-making and social gaze interactions. The ultimate goal of his research is to elucidate the neurophysiological and neuropharmacological mechanisms underlying social cognition and how these processes may be disrupted in psychiatric conditions with social deficits.
  • Jean and David W. Wallace Professor of Comparative Medicine and Professor of Neuroscience and of Obstetrics, Gynecology, and Reproductive Sciences; Chair, Comparative Medicine

    Tamas Horvath is Professor and Chair of the Department of Comparative Medicine and Professor of Neurobiology and Ob/Gyn at Yale University School of Medicine, New Haven, Connecticut. He is also the Director for the Yale Program on Integrative Cell Signaling and Neurobiology of Metabolism. He received a Doctor of Veterinary Medicine (D.V.M.) degree from the Faculty of Veterinary Sciences in Budapest, Hungary, and a Doctor of Philosophy (Ph.D.) degree from the University of Szeged in Hungary. His research has been focusing on neuronal circuitries that support physiological and pathological homeostatic conditions, including processes associated with reproduction, energy metabolism and neurodegeneration.
  • Assistant Professor in Neuroscience; Assistant Professor, Neuroscience

    I have a broad background in signal processing, psychophysics and computational modeling from pre-doctoral and doctoral work. My doctoral research resulted in the first comprehensive model of visual crowding, a ubiquitous phenomenon in peripheral vision that severely degrades our ability to identify objects in clutter. Crowding is especially detrimental in patients with central vision loss. We also demonstrated that the oculomotor system has a remarkable ability to rapidly and persistently adapt to simulated central vision loss in normally sighted human subjects. During my post-doctoral training at the Salk Institute, I employed advanced electrophysiological and optogenetic techniques in the alert non-human primate to investigate the neuronal mechanisms of shape processing and attention in the visual cortex. My research has uncovered the detailed spatio-temporal structure of shape processing in neurons in visual area V4, a critical area for both shape processing and attention. Our results force us to reconsider the established notion that neuronal invariance increases as one traverses the cortical hierarchy. I have investigated the causal role of low-frequency correlated variability in neural activity on attentive behavior. Further, I have uncovered the cortical layer-specific organization of attentional modulation in the visual cortex. Together, these studies promise to significantly advance our current understanding of the cortical circuits of attention.
  • Assistant Professor of Psychiatry and of Neuroscience

    Dr. Hyojung Seo received her bachelor and master's degree in Psychology from Seoul National University in the Republic of Korea. She then completed her Ph.D. in behavioral neuroscience with her thesis research on the neurophysiology of the oculomotor system. Dr. Seo continued her research in decision neuroscience as a post-doctoral fellow and associate research scientist at Yale University and joined the Department of Psychiatry at Yale University as an assistant professor in 2016.
  • Professor of Comparative Medicine and of Ophthalmology and Visual Science; Chief of Pathology, Comparative Medicine

    Caroline Zeiss is a Professor of Comparative Medicine, and holds a joint appointment in the Department of Ophthalmology and Visual Sciences.  She is Chief of Pathology in Comparative Medicine, and established and directed its Pathology Research Core from 2005-2019. Trained as an anatomic pathologist and laboratory animal veterinarian, Dr. Zeiss specializes in comparative neuropathology, ophthalmic pathology and non-human primate pathology. Her experience in neuropathology intersects with her research in animal to human translation of therapies for neurologic disease, and the graduate level course she teaches in comparative neuroanatomy. Similarly, her interest in non-human primate pathology stems from her ongoing clinical role as a laboratory animal clinician, almost exclusively practicing with simians. Dr. Zeiss’ expertise in ophthalmic pathology is informed by her research training in genetics and pathology of large animal models for retinitis pigmentosa. She has published broadly on ocular diseases of laboratory, wild and domestic animals. In collaboration with industry and academic researchers, she performs safety and efficacy pathology studies for ophthalmic interventions. Dr. Zeiss’ research interest focuses primarily on understanding aspects of animal model use that impede translation of promising animal studies to humans. Her interest lies in neurologic disease, particularly in progressive neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases. She has applied biomedical informatics, natural language processing and networks analysis to aid large scale evaluation of animal use patterns and the relationship of these to eventual FDA approval. Prior to these efforts, she led an independently funded laboratory focusing on mechanisms of neurodegeneration in retinitis pigmentosa and age-related macular degeneration. She is the Co-Director of the Alzheimer's Disease Research Center at Yale, specifically to perform comparative neuropathologic analyses of aging primate brains. Most recently, her translational work has broadened with award of two recent COVID grants, one to determine when COVID will reach endemic status, and the other to assess the impact of concurrent influenza and SARS-CoV-2 infection in hamsters.   Dr. Zeiss' contributions to veterinary education have been through her membership on the American Veterinary Medical Association Council on Education (Chair, 2019), the accrediting body for all US, Canadian and some international veterinary schools. She is currently a member of the Institute for Laboratory Animal Research, residing within the National Academy of Sciences. She received her veterinary degree (with distinction) from the University of Pretoria (Onderstepoort) in South Africa. Following an internship in Small Animal Medicine and Surgery (University of Pennsylvania), she completed her Anatomic Pathology Residency training and received her PhD degree from Cornell University.Dr. Zeiss is board certified in Veterinary Anatomic Pathology (2005) and Laboratory Animal Medicine (2012).

Former Members

  • Minji Park
  • Aviva Rabin-Court

    Undergraduate Student

  • Lynn Selemon, PhD

    Research Scientist in Neuroscience