Macaque Brain Resource at Yale (MacBrainResource) has been created to make five distinct collections of macaque brain tissue available to investigators worldwide and thereby provide a cost effective means for researchers to conduct de novo studies on the non-human primate brain without exorbitant costs and without having to sacrifice additional animals. Research on the non-human primate brain is critical to understanding human brain development, architecture, connectivity, and disease. Yet non-human primate research has become exponentially more difficult due to a number of factors, among them the skyrocketing cost of primate procurement, housing, and veterinary care, the time and effort to comply with institutional regulatory guidelines, and growing public concern about the use of non-human primates in research. Study of pre- and postnatal development in the non-human primate is particularly challenging as it requires a breeding colony and specialized facilities to accommodate pregnant, infant and juvenile non-human primates. Drs. Pasko Rakic and Patricia Goldman-Rakic, while in the Department of Neuroscience at Yale, established one of few non-human primate breeding colonies in the world and the only one with the capacity for timed breeding. In their long and productive careers, they produced an immense collection of slides and plastic EM embedded blocks from their non-human primate studies. Given the vast resources that were required to generate these brain materials, duplication would be very difficult today. The mission of MacBrainResource is particularly important and timely in light of the daunting challenges faced by primate researchers. Our goal is to facilitate primate research by enabling neuroscience researchers to access these five valuable collections either on-site or remotely via the web for use in their own research programs.