Maria Ferrara, MD
Assistant Professor Adjunct of PsychiatryCards
About
Titles
Assistant Professor Adjunct of Psychiatry
Biography
Dr. Ferrara's clinical and research interests are focused on improving the care of individuals with psychotic disorders. As staff psychiatrist for the Department of Mental Health and Substance Abuse in Modena, she led the development of an assertive outreach based coordinated service for first episode psychosis in the province of Modena. She helped create implementation protocols, organized educational activities for area mental health professionals and primary care physicians, as well as public awareness events targeting youth, families and community members. She has, since 2012, served as the principal psychiatrist for new onset psychosis services at a community mental health center. In 2017, Dr. Ferrara has joined the research team at the STEP Program where she will help coordinate the implementation and analysis of the NIH-funded STEP-ED project that includes a campaign (MindMap) to reduce the duration of untreated psychosis in a 10 town region surrounding the STEP clinic. Dr. Ferrara’s other research interests include HIV Psychiatry, metabolic side effects of antipsychotic medications, physical health monitoring in severe mental illness, and biomarkers for treatment response in psychosis.
Education & Training
- Resident
- Università degli Studi di Modena e Reggio Emilia, Italy (2012)
- Visiting Scholar
- HIV Neurobehavioral Research Program (HNRP), UCSD, San Diego, CA (2012)
- MD
- Università degli Studi di Modena e Reggio Emilia, Italy (2007)
Research
Publications
2025
The impact of Duration of Untreated Psychosis on functioning and quality of life over one year of Coordinated Specialty Care (CSC)
Hazan H, Tayfur S, Zhou B, Li F, Gibbs-Dean T, Karmani S, Kline E, Ferrara M, Corbera S, Riley S, Sykes L, Tek C, Keshavan M, Srihari V. The impact of Duration of Untreated Psychosis on functioning and quality of life over one year of Coordinated Specialty Care (CSC). PLOS ONE 2025, 20: e0312740. PMID: 39928579, PMCID: PMC11809850, DOI: 10.1371/journal.pone.0312740.Peer-Reviewed Original ResearchConceptsCoordinated specialty careQuality of lifeDuration of untreated psychosisDUP groupWorld Health OrganizationYear of coordinated specialty careGeneralized linear modelConfidence intervalsBinary outcomesGlobal functioningDuration of untreated psychosis groupSymptom severityUntreated psychosisSpecialty careCSC programsImpact of duration of untreated psychosisFunctional gainsModel repeated measuresMixed model repeated measuresOdds ratioNo significant differenceLogit link functionStatus improvementContinuous outcomesSocial functioningSex differences in clozapine prescription: results from an Italian 30-year health records registry
Ferrara M, Domenicano I, Bellagamba A, Zaffarami G, Benini L, Sorio C, Gentili E, Srihari V, Grassi L. Sex differences in clozapine prescription: results from an Italian 30-year health records registry. Journal Of Psychiatric Research 2025 DOI: 10.1016/j.jpsychires.2025.02.019.Peer-Reviewed Original ResearchAntipsychotics to clozapineSchizophrenia spectrum disordersDiagnosis of schizophreniaClozapine prescriptionPrescribed clozapineSpectrum disorderDiagnosis of schizophrenia spectrum disorderBarriers to clozapine useTreatment-resistant schizophreniaOutpatient psychiatric servicesGender-specific biasesClozapine useBackground ClozapineSchizophrenia diagnosisClozapineSchizophreniaSex differencesPrescribed to womenClinical confounding factorsDisordersFemale patientsHazard ratioAntipsychoticsAdequate treatmentPatientsThe Challenging Problems of Cancer and Serious Mental Illness
Grassi L, McFarland D, Riba M, Ferrara M, Zaffarami G, Belvederi Murri M, Cruciata M, Caruso R. The Challenging Problems of Cancer and Serious Mental Illness. Current Psychiatry Reports 2025, 27: 41-57. PMID: 39786658, PMCID: PMC11724792, DOI: 10.1007/s11920-024-01570-9.Peer-Reviewed Original ResearchConceptsSerious mental illnessProblem of cancerMental illnessGeneral populationPhysical health careRates of screeningMental health servicesHealth-care systemMedication side effectsHealth servicesOncology settingUnhealthy lifestyleHealth careCancer preventionStandard cancer treatmentHigher mortalitySomatic disordersCareVulnerable segmentsNegative outcomesIllnessOncologyCancer treatmentDelayed treatmentCancer
2024
The revival of psilocybin between scientific excitement, evidence of efficacy, and real-world challenges
Scala M, Fabbri C, Fusar-Poli P, Di Lorenzo G, Ferrara M, Amerio A, Fusar-Poli L, Pichiecchio A, Asteggiano C, Menchetti M, De Ronchi D, Sub-Project M, Fanelli G, Serretti A. The revival of psilocybin between scientific excitement, evidence of efficacy, and real-world challenges. CNS Spectrums 2024, 29: 570-584. PMID: 39655426, DOI: 10.1017/s1092852924002268.Peer-Reviewed Original ResearchAnxiety disordersPost-traumatic stress disorderPsychedelic-assisted psychotherapyObsessive-compulsive disorderSubstance use disordersPsychotic spectrumStandard antidepressantsResearch to clinical practiceTreating moodStress disorderAddictive behaviorsPsychopharmacological researchPsychiatric conditionsPsilocybinEvidence of efficacyAnxietyMethodological limitationsDisordersMoodMethodological constraintsMethodological rigorEvidence basePotential paradigm shiftLong-term efficacyCultural stigmaCorrelates of Impaired Timing Abilities in Schizophrenia
Croce E, Simonelli G, Ferrara M, Escelsior A, Folesani F, Bovio A, Muscettola A, Toffanin T, De Bellis G, Nanni M, Caruso R, Murri M, Grassi L. Correlates of Impaired Timing Abilities in Schizophrenia. The Journal Of Nervous And Mental Disease 2024, 212: 603-622. PMID: 39808471, DOI: 10.1097/nmd.0000000000001810.Peer-Reviewed Original ResearchSymptom severityTiming abilityDisorganized symptomsNeurobiological correlatesWorking memoryExecutive functionTiming impairmentsNeurobiological dataSchizophreniaCognitive impairmentNeural circuitsImpairmentSymptomsPreferred Reporting ItemsSystematic literature searchClinical heterogeneityCognitionAbilitySeverityReporting ItemsMemoryStudy designSystematic reviewPsycINFOAssociationThe anomalous effect of COVID-19 pandemic restrictions on the duration of untreated psychosis
Nicholls-Mindlin J, Hazan H, Zhou B, Li F, Ferrara M, Levine N, Riley S, Karmani S, Mathis W, Keshavan M, Srihari V. The anomalous effect of COVID-19 pandemic restrictions on the duration of untreated psychosis. BJPsych Open 2024, 10: e216. PMID: 39628123, PMCID: PMC11698182, DOI: 10.1192/bjo.2024.813.Peer-Reviewed Original ResearchAdolescents with first-episode psychosis and clinical high risk in the Province of Ferrara: an audit on the implementation of a specialised early intervention program
Magnabosco V, Ferrara M, Domenicano I, Cruciata M, Sarela A, Emanuelli F, Grassi L. Adolescents with first-episode psychosis and clinical high risk in the Province of Ferrara: an audit on the implementation of a specialised early intervention program. International Journal Of Psychiatry In Clinical Practice 2024, 28: 224-234. PMID: 39810320, DOI: 10.1080/13651501.2024.2446777.Peer-Reviewed Original ResearchConceptsClinical high riskFirst-episode psychosisGeneral practitionersSpecialised mental health careStandardised assessmentMental health careQuality improvement initiativesAdolescent mental healthAdult psychiatric servicesHigh riskCAMH careCAMH servicesEarly intervention programsHealth careSub-optimal adherenceImprovement initiativesMental healthPsychiatric hospitalisationPsychiatric servicesPharmacological prescriptionsDrug prescribingIntervention programsDescriptive statisticsPsychiatric differential diagnosisPsychiatric unitA tale of two constructs: combined assessment of demoralization and subjective incompetence
Murri M, Folesani F, Azzolina D, Muscettola A, Bobevski I, Triolo F, Farkas G, Braccia F, Gavesi M, Toffanin T, Ferrara M, Zerbinati L, Khan M, Gregori D, De Figueredo J, Kissane D, Caruso R, Grassi L, Nanni M. A tale of two constructs: combined assessment of demoralization and subjective incompetence. Psychology Health & Medicine 2024, 29: 1635-1651. PMID: 39302008, DOI: 10.1080/13548506.2024.2405749.Peer-Reviewed Original ResearchConceptsSubjective incompetenceClinical dimensionsItem response theory analysisLatent trait scoresItem psychometric propertiesShort assessment instrumentDimension of demoralizationItem response theory modelsTrait scoresItem structurePsychometric propertiesDemoralization ScaleAssessment instrumentsDemoralizationIRT modelsTwenty itemsLong versionItemsDiscriminative propertiesClinical assessmentGeneral populationTheory analysisMultiple dimensionsHopelessnessEarly signsTimelinePTC: Development of a unified interface for pathways to care collection, visualization, and collaboration in first episode psychosis
Mathis W, Ferrara M, Cahill J, Karmani S, Tayfur S, Srihari V. TimelinePTC: Development of a unified interface for pathways to care collection, visualization, and collaboration in first episode psychosis. PLOS ONE 2024, 19: e0302116. PMID: 39028697, PMCID: PMC11259254, DOI: 10.1371/journal.pone.0302116.Peer-Reviewed Original ResearchConceptsPathways to CareDuration of untreated psychosisManual transcription errorsDevelopment of targeted interventionsReduce duration of untreated psychosisHealthcare accessibility researchReal-time data entryImprove patient outcomesEpisode psychosisCare pathwaysPatient journeyHealthcare contextPatient outcomesPaper-basedConversion of collected dataFEP treatmentData collection processNew HavenData collection methodsData entryTranscription errorsUntreated psychosisOpen-source codebaseData collectionWeb-based toolFirst episode psychoses in people over-35 years old: uncovering potential actionable targets for early intervention services
Ferrara M, Domenicano I, Marchi A, Zaffarami G, Onofrio A, Benini L, Sorio C, Gentili E, Murri M, Toffanin T, Little J, Grassi L. First episode psychoses in people over-35 years old: uncovering potential actionable targets for early intervention services. Psychiatry Research 2024, 339: 116034. PMID: 38906051, DOI: 10.1016/j.psychres.2024.116034.Peer-Reviewed Original ResearchLong-acting injectable antipsychoticsFirst-episode psychosisEarly intervention servicesPrescribing long-acting injectable antipsychoticsNon-affective first-episode psychosisIntervention servicesCommunity psychiatric servicesInjectable antipsychoticsPsychotic onsetEpisode psychosisAffective psychosisPsychiatric servicesPsychosisExclusion of patientsAccess treatmentClinical characteristicsRetrospective studyOlder patientsPatientsAntipsychoticsAntidepressantsAge groupsWomenGroupIndividuals